疏肝健胃解郁方加减对功能性消化不良胃敏感性影响的临床研究

Clinical Study on the Effects of Shu Gan Jian Wei Jie Yu Formula on Gastric Hypersensitivity in Patients with Functional Dyspepsia

目的:评价疏肝健胃解郁方加减对功能性消化不良(functional dyspepsia FD)患者胃敏感性的影响。方法:将64例患者随机分为治疗组和对照组,每组各32例,治疗组以疏肝健胃解郁方化裁、对照组以多潘立酮治疗,疗程为4周;并设20例健康志愿者为健康对照组;采用饮水负荷实验(Water-drink test,WDT)检测FD患者治疗前后及健康对照组胃敏感性。结果:FD在胃感知阈值、胃饱足阈值及胃最大耐受阈值方面均明显低于健康对照组(P<0.01);中药组和西药组均能改善FD患者胃感知阈值、胃饱足阈值及胃最大耐受阈值(P<0.05),且中药组由于西药多潘立酮(P<0.05);同时中药组在胃阈值改善率方面优于西药组(P<0.05);不同中医证型胃感知阈值、胃饱足阈值及胃最大耐受阈值存在差异,以脾胃气虚组最明显,相对于其它证型有统计学意义(P<0.05)。结论:中药疏肝健胃解郁方加减可能通过改善FD患者胃敏感性而达到治疗目的。

Objective： This study aims to determine the efficacy of Shu Gan Jian Wei Jie Yu formula on gastric hypersensitivity in patients with functional dyspepsia （FD）. Methods：This study is a randomized demperidone - controlled triM. Sixty - four FD patients were randomized to receive either Shu Gun Jian Wei Jie Yu formula （treat group） or domperidone （control group） for 4 weeks;and 20 healthy people were recruited （ normal group）. The primary outcome and after treatment outcome are the patient＇ s gastric （visceral） hypersensitivity （response to water drink test）. Results： effective rate in these parameters （threshold for first sensation,threshold for satiety,threshold for highest tolerance） in Shu Gun Jian Wei Jie Yu formula have significant higher than those in the domperidone - controlled group （ P 〈 0.05 ）. There also exist difference in these parameters in different TCM syndromes and that of qi - deficiency of spleen and stomach group is the lowest than that of other three syndromes （ P 〈 0.05 ）. Conclusion：Gastric Hypersensitivity may plays an important role in the etiology of FD, Shu Gun Jian Wei Jie Yu formula could lower gastric hypersensitivity in FD patients to improve symptoms.