理冲汤加减方联合化疗治疗晚期卵巢癌的临床研究

Clinical Research on Effect of Changed Lichong Decoction Combined Chemotherapy in The Treatment of Advanced Ovarian Cancer

目的:评价中药理冲汤加减方联合化疗治疗晚期卵巢癌的临床疗效。方法:将70例卵巢癌患者随机分为两组,治疗组(35例)于化疗第2天服用理冲汤加减方,水煎服每日1剂,至下1周期化疗开始,共20天;对照组(35例)单独使用化疗药物,化疗结束后不再用药。观察化疗药物消化道不良反应、患者生活质量、血液流变、血小板膜糖蛋白在治疗前后的变化,评价疗效。结果:两组治疗后与治疗前比较,血液流变高、中、低切值、血浆黏度、消化道反应、生活质量、CD62P表达,差异均有显著性(P<0.05);两组治疗后比较,血流变中、低切值、血浆黏度、消化道反应、生活质量、CD62P表达,差异均有显著性(P<0.05)。结论:理冲汤加减方联合化疗对晚期卵巢癌的治疗在减轻消化道反应方面疗效显著,可使患者血栓前状态得以改善,可能对减少卵巢癌病变复发转移有意义。

Objective：To evaluate the clinical efficacy of changed Lichong decoction plus chemotherapy for advanced ovarian carcinoma. Methods ：70 advanced ovarian carcinoma patients were randomly divided into two groups ：treatment group in which 35 patients were treated with chemotherapy plus changed Lichong decoction and control group treated with simple chemotherapy. The digestive tract reactions of chemotherapy, quality of life, blood flow and platelet membranous glycoprotein were observed before and after treatment. Results ： The levels of blood flow, blood plasma, digestive reactions, quality of life as well as the expression of CD62P after treatment were significantly changed in both groups with significant difference as compared with those before treatment （ both P 〈 0.05 ） ; And comparison between the two groups in the levels of blood flow, blood plasma, digestive reactions, quality of life as well as the expression of CD62P aftertreatment also showed significant difference （ P 〈 0. 05 ）. Conclusion ： Lichong decoction plus chemotherapy is effective to alleviate digestive tract adverse reactions, improve quality of life, alter blood flow, and change the expression of platelet membranous glycoprotein,and is importance to resist the recurrence and metastasis of advanced ovarian carcinoma.