运用动脉自旋标记技术研究大脑中针刺效应的展望

Application of Arterial Spin Labeling Technique in Studying Acupuncture Effect on the Brain

动脉自旋标记(ASL)灌注成像是以动脉血作为内源性示踪剂、无创性观测血流灌注情况的磁共振检查新技术。它可对局部脑血流量(rCBF)进行绝对测量,弥补由于BOLD信号低所致结果可重复性差的缺陷,交叉验证当前针刺效应研究中BOLD–fMRI成像结果,使研究结论更具推广意义,为无创、实时、可视化地研究人脑中针刺效应提供了新的手段。本文对ASL技术的成像原理、应用于中枢神经系统的现状、与BOLD–fMRI技术的比较、在针刺效应研究方面的应用价值进行了总结。

Magnetic resonance perfusion imaging of arterial spin labeling （ASL） is a technique to noninvasively measure the blood flow using the labeling arterial blood as an endogenous tracer. It can quantificationally measure the local cerebral blood flow, make up the defect of bad repeatability due to low BOLD signal and cross validate the imaging result of BOLD fMRI, more meaningful to put research results forward. It provides a new technique for noninvasively, timely and visibly studying the acupuncture effect on the human brain. This paper is to summarize the imaging theory of ASL, the current situation of ASL application in CNS,its comparison to BOLD fMRI, and its value on the aspect of aeupuneture research.