高危型人乳头瘤病毒感染状况和年龄分布

Prevalence and Age Distribution of High-risk Human Papillomavirus Infection in Women

目的探讨妇女高危型人乳头瘤病毒（human papilloma virus,HPV）感染状况及年龄分布。方法 2008年7月—2010年12月在我院妇科门诊就诊的1 350例妇女,采用实时荧光定量PCR技术检测高危型HPV,将筛查人群分为8个年龄段,分别计算各年龄段妇女高危型HPV阳性率,分析高危型HPV阳性率与年龄段的关系。结果在1 350例妇女中共检出高危型HPV妇女315例,阳性率为23.3%。不同年龄妇女高危型HPV阳性率间差异有统计学意义（χ2=176.71,P〈0.05）,其中41~45岁和46~50岁这两个年龄段的阳性率高,以41~45岁为最高。结论检测妇女高危型HPV可为宫颈癌的早期诊断、预防及疗效观察提供实验诊断依据。

Objective To investigate the prevalence and age distribution of high-risk human papillomavirus（HD-HPV） Infections in women.Methods The clinical data of 1350 women who visited the department of gynecology of our hospital from July 2008 to December 2010 were retrospectively reviewed.Patients were divided into 8 different age groups,and the prevalence of HR-HPV infections was calculated in each group according to the real-time fluorescence quantitative polymerase chain reaction（FQ-PCR） findings.The relationship between prevalence and age was analyzed.Results A total of 315 women（23.3%） were found to be positive with HR-HPV..In addition,the prevalence of HR-HPV infections was significantly different among different age groups,with the 40~45 age group had the highest prevalence,followed by and 46~50 age group.Conclusion Screening for HR-HPV infection can provide laboratory evidences for the early diagnosis,prevention,and treatment of cervical cancer.