摘要
为了探讨红细胞膜钠-锂逆转换活性(SLCA)与Ⅱ型糖尿病血脂异常之间的关系,采用Fujita等的方法,测定了81例Ⅱ型糖尿病患者、40例正常人的SLCA,并对其血脂水平和胰岛素敏感性指数(ISI)进行检测,结果显示Ⅱ型糖尿病患者SLCA(0.361±0.139mmol/L RBC/h)明显高于正常对照(0.191±0.083mmol/L·RBC/h)(P<0.01);分别以SLCA和ISI为应变量作逐步回归分析,发现SLCA与ISI、HDL2呈负相关,与TG呈正相关;ISI与HDL2正相关,与TG呈负相关。提示(1)SLCA在Ⅱ型糖尿病升高,(2)SLCA与Ⅱ型糖尿病胰岛素敏感性及其脂代谢异常有关,并可能作为反映Ⅱ型糖尿病机体胰岛素敏感性指标之一。
To investigate the relation between erythrocyte sodium-lithium countertransport activity (SLCA) anddyslipidemia in type II diabetes mellitus, SLCA was measured according to the method described by Fujita in 81type II diabetes and 40 healthy control subjects, and their plasma lipids and insulin-sensitivity index (ISI) wasmeasured also. The results showed that SLCA was significantly higher in type II diabetes (0.361±0.139 mmol/L. RBC / h) than that in healthy control subjects (0.191±0.083 mmol /L. RBC / h ) (P<0.01). A stepwisemultiple regression analysis was conducted using SLCA or ISI as the dependent variable. It was found that SLCAwas negatively correlated with ISI and HDL^2, and was positively correlated with TG; ISI was positivelycorrelated with HDL^2 and was negatively correlated with TG. This study suggested that (1) erythrocyte SLCAwas increased significantly in type II diabetes; (2) erythrocyte SLCA was related to insulin-sensitivity anddyslipidemia in type II diabetes, and the elevation of SLCA can be used as one of the indexes for the evaluationof insulin - sensitivity in type II diabetes mellitus.
出处
《重庆医科大学学报》
CAS
CSCD
1999年第4期347-349,共3页
Journal of Chongqing Medical University