红细胞膜钠-锂逆转换活性与Ⅱ型糖尿病血脂异常关系研究

Erythrocyte sodium - lithium countertransport activity and dyslipidemia in type II diabetes mellitus

为了探讨红细胞膜钠－锂逆转换活性（ＳＬＣＡ）与Ⅱ型糖尿病血脂异常之间的关系，采用Ｆｕｊｉｔａ等的方法，测定了８１例Ⅱ型糖尿病患者、４０例正常人的ＳＬＣＡ，并对其血脂水平和胰岛素敏感性指数（ＩＳＩ）进行检测，结果显示Ⅱ型糖尿病患者ＳＬＣＡ（０．３６１±０．１３９ｍｍｏｌ／Ｌ ＲＢＣ／ｈ）明显高于正常对照（０．１９１±０．０８３ｍｍｏｌ／Ｌ·ＲＢＣ／ｈ）（Ｐ＜０．０１）；分别以ＳＬＣＡ和ＩＳＩ为应变量作逐步回归分析，发现ＳＬＣＡ与ＩＳＩ、ＨＤＬ２呈负相关，与ＴＧ呈正相关；ＩＳＩ与ＨＤＬ２正相关，与ＴＧ呈负相关。提示（１）ＳＬＣＡ在Ⅱ型糖尿病升高，（２）ＳＬＣＡ与Ⅱ型糖尿病胰岛素敏感性及其脂代谢异常有关，并可能作为反映Ⅱ型糖尿病机体胰岛素敏感性指标之一。

To investigate the relation between erythrocyte sodium-lithium countertransport activity (SLCA) anddyslipidemia in type II diabetes mellitus, SLCA was measured according to the method described by Fujita in 81type II diabetes and 40 healthy control subjects, and their plasma lipids and insulin-sensitivity index (ISI) wasmeasured also. The results showed that SLCA was significantly higher in type II diabetes (0.361±0.139 mmol/L. RBC / h) than that in healthy control subjects (0.191±0.083 mmol /L. RBC / h ) (P<0.01). A stepwisemultiple regression analysis was conducted using SLCA or ISI as the dependent variable. It was found that SLCAwas negatively correlated with ISI and HDL^2, and was positively correlated with TG; ISI was positivelycorrelated with HDL^2 and was negatively correlated with TG. This study suggested that (1) erythrocyte SLCAwas increased significantly in type II diabetes; (2) erythrocyte SLCA was related to insulin-sensitivity anddyslipidemia in type II diabetes, and the elevation of SLCA can be used as one of the indexes for the evaluationof insulin - sensitivity in type II diabetes mellitus.