亚临床肝性脑病的脑干听觉诱发电位研究

Study of brainstem auditory evoked potentials in subclinical hepatic encephalopathy

目的 探讨脑干听觉诱发电位（ＢＡＥＰ）对亚临床肝性脑病的诊断意义。方法 对２９ 例肝硬化失代偿期患者及３０ 例正常对照者进行ＢＡＥＰ 检测并行对比分析。结果 病例组Ⅲ、Ⅴ波潜伏期（ＰＬ） 及Ⅰ～Ⅴ波峰间期（ＩＰＬ） 延长，与对照组相比差异有显著性（ Ｐ＜ ０－０５）。以大于对照组各波ＰＬ及ＩＰＬ的－ｘ ＋ ３ｓ 为异常标准，ＢＡＥＰ 异常率４４－８％ （１３／２９） 。结论 失代偿期肝硬化患者脑干桥脑以上中枢段传导通路存在损害，ＢＡＥＰ对亚临床肝性脑病早期诊断有一定临床意义。

Objective\ To study the clinical significance of brainstem auditory evoked potentials(BAEP) in subclinical hepatic encephalopathy(SHE). Methods\ 29 patients with decompensated hepatic cirrhosis and 30 normol controls were examined by BAEP. Results\ Compared with control group, patients waves Ⅲ、Ⅴpeak latency(PL)and wavesⅠ～Ⅴinterpeak latency(IPL)were delayed,which was significantly different between the two groups ( P <0 05). If the abnormal level was higher than +3s , BAEP showed 44.8% abnormalities. Conclusion\ There is damage of the central pathes above the pons in patients with decompensated hepatic cirrhosis.BAEP has certain value for early diagnosis in SHE.