培哚普利与硝苯地平对高血压并Ⅱ型糖尿病左室肥厚及肾功能的影响

Effects of acertil or nifedipine on the left ventricular hypertrophy and the renal function in patients of HP with Ⅱ DM

目的 探讨培哚普利与硝苯地平对高血压并Ⅱ型糖尿病患者左室肥厚及肾功能的影响。方法 将符合研究对象的６５ 例患者分为培哚普利组和硝苯地平组，分别记录治疗前及治疗后空腹血糖、血压、左室舒张末期内径、左室舒张末期后壁厚度、左室心肌重量指数、２４ ｈ 尿蛋白、肾功能。结果 培哚普利组较治疗前上述指标有明显改善（ Ｐ＜ ０－０５ 或Ｐ＜ ０－０１） ，且治疗８ 个月后上述指标改善培哚普利组较硝苯地平组差异均有显著性（ Ｐ＜ ０－０５ 或Ｐ＜ ０－０１） 。结论 培哚普利能逆转左室肥厚及改善肾功能。

Objective To understand the effects of acertil or nifedipine on the left ventricular hypertrophy and the renal function in patients of HP with Ⅱ DM. Methods 65 cases were divided into two groups, one group treated by acertil and another group by nifedipine. The free BG、 BP、 LVDd、 LVMI、 UPr/24 h、 renal function were recorded before and after treatments. Results All the indexes above in acertil group were not only improved ( P< 0 05, P< 0 01), but also improved more than those in nifedipine group ( P< 0 05, P< 0 01) after 8 months. Conclusion Acertil can reverse left ventricular hypertrophy and improve the renal function.