酪酸菌制剂治疗儿童幽门螺杆菌感染的临床观察

Clinical analysis of butyric acid bacillany drugs in childrens helicobacter pylori infection

目的 探讨酪酸菌制剂对儿童幽门螺杆菌（ＨＰ） 根除的效果。方法 经尿素酶试验和ＰＣＲ 检查阳性确诊为ＨＰ感染患儿３７ 例，随机分为酪酸菌治疗组（２３ 例） 和铋剂对照组（１４ 例） 。两组分别以酪酸菌制剂和枸橼酸铋钾，联合羟氨苄青霉素、甲硝唑治疗。结果 两组上消化道症状缓解时间和症状消失时间基本相同，ＨＰ 根除率、胃炎好转率和胃溃疡治愈率两组差异无显著性（ Ｐ＞ ０－０５） 。但铋剂组不良反应率高于酪酸菌制剂组。结论 酪酸菌制剂联合二种抗生素治疗儿童ＨＰ 感染根除率高且不良反应率低，宜推广使用。

Objective To explore the eradicating effect of butyric acid bacillary drug in childrens helicobacter pylori(HP) infection. Methods HP infection in 37 cases diagnosed by urease test and PCR were classified into two groups of treatment. One group (23 cases) was given butyric acid bacillany drugs,another group (14 cases) given bismuthic kalicitratiz. Meanwhile the cases were given amoxcillin and metronidazole. Results The relief symptom of upper digestive tract, discontinuing time, eradication rate, gastritis better rate and gastric ulcer cure rate were almost same without conspicuous difference. The side effect in bismuthi drug group was higher than butyric acid bacillary drug( P <0 05). Conclusion Combining butyric acid bacillary drug with two antibiotics in the HP affected children,eradication rate is high and curative effect good. There is little side effect. It is valuable for the popularization of its clinical use.