1743例老中青人群肾功能状况分析

Analysis of renal function on 1743 people of different ages

目的：为了解和评估老中青人群肾功能各参数现状与相关性。方法：对１ ７４３ 例不同年龄（２０ ～８５ 岁） 人群分成Ａ，Ｂ，Ｃ，Ｄ，Ｅ 和Ｆ 组，分别测定尿微量白蛋白（Ａｌｂ） 、视黄醇结合蛋白（ＲＢＰ） ，βＮ乙酰氨基葡萄糖苷酶（ＮＡＧ） 、渗透压和血清尿素氮（ＢＵＮ） 、血尿酸（ＵＡ） 及内生肌酐清除率（Ｃｃｒ） 等肾功能参数。结果：尿ＮＡＧ 和尿ＲＢＰ 两参数在Ａ，Ｂ（２０ ～４０ 岁） 两组比较差别无显著性（ Ｐ ＞ ０ ．０５） ；而Ａ 组分别与Ｃ，Ｄ，Ｅ 和Ｆ 组比较，差别有显著性（ Ｐ ＜ ０ ．０５ 或Ｐ ＜ ０ ．０１） ；尿Ａｌｂ ，Ａ 组与各组比较差别有非常显著性（ 均Ｐ ＜ ０ ．０１） ；Ｅ 和Ｆ 两组比较差别无 显著性（ Ｐ ＞ ０ ．０５） ；Ｃｃｒ 在Ｂ，Ｃ，Ｄ，Ｅ，Ｆ 组分别比Ａ 组下降８－５ ％ ，１７－８ ％ ，２９－９ ％ ，４２－９ ％ 和５６－３ ％ ；尿渗透压和血Ｃｒ，ＢＵＮ，ＵＡ 在各组间差别无显著性（ 均Ｐ ＞ ０ ．０５） 。结论：Ｃｃｒ 各年龄段都存在不同程度下降，以５０ 岁后下降明显，肾小管功能损害在４０ 岁以前不明显，５０ 岁后ＮＡＧ，ＲＢＰ 显著增高；７０ 岁后趋向稳定；故４１ ～７０ 岁之间是肾功能下降明显时期。

Objective: To understand and evaluate the currency and correlation between parameters about renal function. Methods: We divided 1?743 people whose ages vary from 20～85 years into six groups(A,B,C,D,E,F). Urinary Mini Albumin, RBP, NAG, osmotic pressure, serum BUN, plasma UA and internal creatinine clearance were measured as parameter about renal function. Results: There was no obvious difference between the Group A and Group B(P>0.05); The mean value of urinary NAG and urinary RBP in the two gorup was 10.9650±6.5650 and 0.1885±0.4709; However, when they were compared with the values of C,D,E group respectively, there were promintent differences(P<0.05 or P<0.01). Urinary Alb value of Group A is quite different from other groups. No difference exists between urinary Alb value of Group E and Group F(P>0.05). Internal creatinin elearance decrease by the rate of 8.5%,17.8%,29.9%,42.9% and 56.3% when Groups B,C,D,E and F was compared with Group A; while urinary osmotic pressure and the value of plasma BUN, Cr and UA has no obvious difference between any two groups(P>0.05). Conclusion: The clearance of internal creatinine decrease with the growing of the age, especially older than 50 years of agc. The parameter about tubular injury increas obviously after 40 years old though it does not change prominently before 50 years old, while it tends to be stable after 70 years old. We think it is during period of 40 to 70 years old that the renal function decreases more rapidly.