丹参对耳蜗辐射防护作用的实验研究

Protective effect of Radix Salvia Miltiorrhizae on radiation damage of the cochlea

为探讨内耳辐射损伤的防治，采用丹参作为保护药物，用相同剂量的６０Ｃｏ γ射线照射丹参防护组和单纯放射组豚鼠耳颞部，２ 周后作形态与机能检查。结果发现：丹参防护组耳蜗机能与结构损害较轻，而单纯放射组耳蜗机能明显受损，血管纹和柯替氏器病变严重；复合动作电位（ＣＡＰ） 反应阈和毛细胞损伤率两组比较差异有显著性（ Ｐ ＜ ０ ．０１） 。表明丹参对内耳辐射损伤有保护作用。

In order to evaluate the preventive and therapeutic effects of Radix Salvia Miltiorrhizae on radiation damage of the cochlea, guinea pigs were divided into 3 groups. Group 1 was treated by radiation added with Radix Salvia Miltiorrhizae. Group 2 was radiated alone, and Group 3 was control. Group 1 and Group 2 were radiated with a single dose of gamma radiation(60?Gy). Morphological and functional observation of the cochleae was performed in two weeks after radiation. The result showed that the changes of complex action potential(CAP) and the cochlear structure were slight in Group 1, but obvious changes were found in Group 2. There was a significant difference in CAP response threshold and incidence of the cochlear hair cell loss between Group 1 and Group 2(P<0.01). These results suggest that Radix Salvia Miltiorrhiza may prevent radiation induced cochlea damage. Its protective mechanisms may be cleaning free radicals, blocking calcium channel and improving microcirculation of the cochlea.