辛伐他汀在骨代谢中作用的研究进展

Research progress on the use of simvastatin in bone metabolism

辛伐他汀是羟甲基戊二酰辅酶A还原酶的特异性抑制剂,抑制内源性胆固醇的合成。近年的研究发现:辛伐他汀可促进成骨细胞增殖和骨形成增加,因此,学者们越来越关注该药在骨改建方面的应用。大量的研究表明:将不同载体携带的辛伐他汀局部应用于各种不同的动物模型可产生不同的促骨形成效果。辛伐他汀在体内应用促进骨形成的效果取决于局部的给药质量浓度,人们一直在努力寻找合适的给药途径。本文就辛伐他汀对骨再生所产生的影响、机制、载体和剂量等作一综述。

Simvastatin is a specific hydroxymethyl glutaryl coenzyme A reductase inhibitor,which inhibits endogenous cholesterol synthesis.Recent studies have found that simvastatin could promote osteoblasts proliferation and increase bone formation,so the scholars are increasingly concerned about the drug in the application of bone remodeling.There have been a large number of studies demonstrating the bone-promoting effect of local application with different carriers in various animal models.The effect of simvastatin for bone formation in vivo depends on the concentration of local administration,and people have been trying to find a suitable route of administration.The effects of the drug on the bone metabolism and its mechanism,dosage,carrier are summarized.