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nell-1型基因成骨及其在骨组织工程中的应用 被引量：1

Research progress on the osteogenesis effect of nel-like typeⅠgene and its application in bone tissue engineering
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摘要 nel样Ⅰ型基因是一种在颅缝早闭者早闭区过度表达的新型基因,因其具有极强的诱导成骨细胞分化和促进新骨形成的生物学功能,被作为新型生长因子用于骨组织工程。本文就nel样Ⅰ型基因成骨及其在骨组织工程中的应用等研究进展作一综述。 Nel-like typeⅠgene is a novel gene which was found overexpressed in pre-fused areas of craniosynostosis patients.It was applied in bone tissue engineering as a new growth factor because of its biological functions on inducing osteoblast differentiaton and enhancing osteogenesis effect.This article will summary a review about the osteogenesis effect of nel-like typeⅠgene and its application in bone tissue engineering according what we have known.
作者 刘琦 李祖兵
机构地区 口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室武汉大学口腔医学院
出处 《国际口腔医学杂志》 CAS 2011年第3期364-366,共3页 International Journal of Stomatology
基金 国家自然科学基金资助项目(30872892)
关键词 nel样Ⅰ型基因 生长因子 成骨作用 组织工程 nel-like typeⅠgene growth factor osteogenesis tissue engineering
分类号 R318.08 [医药卫生—生物医学工程] R782 [医药卫生—口腔医学]
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参考文献17

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  • 2Watanabe TK, Katagiri T, Suzuki M, et al. Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats[J]. Genomics, 1996, 38(3) :273-276.
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国际口腔医学杂志
2011年 第3期

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