乙酰肝素酶的病理生理作用及其在肾脏病的研究进展
摘要
乙酰肝素酶系一种内源性葡糖苷酸内切酶,能特异性地水解硫酸乙酰肝素侧链,调节细胞外基质降解,并释放多种与硫酸乙酰肝素侧链结合的生物活性因子,参与多种生理和病理过程,并在肾小腺疾病特别是在白尿的发生发展过程中发挥重要病理作用。
出处
《国际泌尿系统杂志》
2011年第3期386-389,共4页
International Journal of Urology and Nephrology
参考文献18
-
1Nasser NJ.Heparanase involvement in physiology and disease.Cell Mol Life Sci,2008,65 (11):1706-1715.
-
2Szymczak M,Kuniar J,Klinger M.The role of heparanase in diseases of the glomeruli.Arch Immunol Ther Exp,2010,58(1):45-56.
-
3Hulett MD,Freeman C,Hamdorf BJ,et al.Cloning of mammalian heparanase,an important enzyme in tumor invasion and metastasis.Nat Med,1999,5(7):803 -809.
-
4Abboud-Jarrous C.,Atzmon R,Peretz T,et al.Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment.J Biol Chem,2008,283(26):18167-18176.
-
5Bitan M,Polliack A,Zecchina G,et al.Heparanase expression in human leukemias is restricted to acute myeloid leukemias.Exp Hematol,2002,30(1):34-41.
-
6Nobuhisa T,Naomoto Y,Okawa K,et al.Translocation of heparanase into nucleus results in cell differentiation.Cancer Sci,2007,98 (4):535 -540.
-
7Ostrovsky O,Korostishevsky M,Shafat I,et al.Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression:possibility of multiple levels of heparanase regulation.J Leukoc Biol,2009,86(2):445 -455.
-
8Ilan N,Elkin M,Vlodavsky I.Regulation,function,and clinical significance of heparanase in cancer metastasis and angiogenesis.Int J Biochem CeU Biol,2006,38(12):2018 -2039.
-
9vanden Hoven MJ,Waanders F,Rods AL,et al.Regulation of glomerular heparanase expression by aldosterone,angiotensin JJ and reactive oxygen species.Nephrol Dial Transplant.2009; 24(9):2637 -2645.
-
10Baraz L,Haupt Y.Elkin M,et al.Tumor suppressor p53 regulates heparanase gene expression.Oncogene,2006,25(28):3939-3947.
-
1方志红.精子蛋白17的研究进展[J].实用医技杂志,2009,16(4):289-291.
-
2许广萍,龚茜玲,何莲芳.吗啡-3-葡糖苷酸(M3G)对伤害性刺激诱导大鼠脊髓c-fos表达的影响[J].生理学报,1995,47(1):80-84. 被引量:2
-
3郭真真,戴秋艳.MicroRNA在腹主动脉瘤发生中的调控机制[J].国际心血管病杂志,2014,41(3):179-181. 被引量:3
-
4王永欣,周家德.细胞外基质降解相关因子与宫颈癌[J].安徽医药,2010,14(6):727-730. 被引量:10
-
5陶诗聪,郭尚春,张长青.长链非编码RNA在骨关节炎中的作用[J].国际骨科学杂志,2016,37(6):378-382. 被引量:2
-
6刘丽琼,骆嘉,柯尊记.细胞因子与酒精性肝病[J].生命科学,2010,22(12):1241-1246. 被引量:1
-
7刘艺,沈龙海.骨关节炎关节软骨细胞外基质降解靶点的研究进展[J].世界临床药物,2015,36(5):353-357. 被引量:4
-
8王怡斐,张文高,张玲.中药干预细胞外基质降解稳定动脉粥样硬化斑块的研究进展[J].中西医结合心脑血管病杂志,2008,6(9):1062-1064.
-
9曹登瑞,乔钦增,赵卫林,郭全合,王立锋.哮喘患者诱导痰血管内皮生长因子和基质金属蛋白酶-9的水平和相关性研究[J].山西医药杂志(上半月),2009,38(3):224-225. 被引量:1
-
10李燕杰,李淑莲.乙酰肝素酶的分子特性及其在生理病理过程中的作用[J].河南大学学报(医学版),2008,27(3):14-19. 被引量:4