阿托伐他汀对不稳定心绞痛患者内皮素-1和一氧化氮的影响

Effect of atorvastain on endothelin-1 and nitric oxide in patients with unstable angina pectoris of coronary heart disease

目的:观察阿托伐他汀治疗不稳定型心绞痛疗效及其对内皮素-1(endothelin-1,ET-1)和一氧化氮(nitric oxide,NO)的影响。方法:将不稳定型心绞痛患者随机分为治疗组(n=45)和对照组(n=45),2组均给予同样的常规治疗,治疗组加用阿托伐他汀,均治疗2个月后观察治疗前后心绞痛疗效,检测ET-1和NO水平变化。结果:治疗组可以改善心绞痛症状,降低ET-1水平,提高NO水平,与对照组比较差异有统计学意义(P<0.05或P<0.01)。结论:阿托伐他汀可以通过调节内皮功能,稳定冠状动脉粥样硬化斑块,从而改善心绞痛临床症状。

Objective To observe the effect of atorvastain on endothelin-1（ET-1） and nitric oxide（NO） in patients with unstable angina pectoris of coronary heart disease.Methods Ninety patients with unstable angina pectoris were randomly assigned to a control group（n=45） and a treatment group（n=45）.Two groups were given conventional treatment.The treatment group was treated with atorvastain at same time.After 2 month treatment,the efficacy for angina pectoris was evaluated.The levels of plasma ET-1 and NO were examined.Results Compared with the control group,the levels of ET-1 significantly decreased in the treatment group,concomitantly with an increase in the levels of NO and the improved efficacy for angina pectoris（P〈0.05）.Conclusion Atorvastain could stabilize coronary artery atherosclerotic plaque and improve angina clinical symptoms by inhibition of endothelial dysfunction.