河西走廊中段地区上消化道疾病患者幽门螺杆菌感染状况

The prevalence of Helicobacter pylori infection among patients with an upper gastrointestinal tract disease in the middle of the Hexi Corridor

目的探讨河西走廊中段地区上消化道疾病患者幽门螺杆菌(Hp)感染状况,分析Hp感染与上消化道疾病的关系。方法收集上消化道疾病患者胃粘膜石蜡标本及病理资料,采用W-S银染和革兰染色检查患者组织中Hp感染状况,分析Hp感染与性别、年龄及病理特征之间的关系。结果受检标本Hp阳性率为81.3%(178/219)。浅表性胃炎组、癌前病变组和胃癌组Hp阳性率依次为60.7%、77.4%和85.6%。浅表性胃炎组Hp感染率与胃癌组比较差异有统计学意义(P<0.05);61岁以上组Hp感染率与60岁以下各组比较差异有统计学意义(P<0.05);有淋巴结转移胃癌组Hp感染率与无转移组比较差异有统计学意义(P<0.05);Hp感染率在不同性别、不同胃癌组织病理类型、癌组织大小及浸润深度间差异无统计学意义(P>0.05)。结论在河西走廊中段地区胃癌的发生及其淋巴结转移与Hp感染有关。Hp感染率随年龄增大呈上升趋势。

Objective To determine the prevalence of Helicobacter pylori （Hp） infection among patients with upper gastrointestinal tract disease in the middle of the Hexi Corridor and analyze the relationship between Hp infection and upper gastrointestinal tract disease. Methods Samples of gastric mucosa were embedded in paraffin and pathologic data were collected from patients. Warthin-Starry silver staining and Gram staining were used to detect Hp infection in the samples. The relationship between Hp infection and sex, age, and clinicopathologic features was studied. Results The rate of Hp infection was 81.3% in all samples （178/219） and 85, 6% in patients with gastric cancer, 77.4% in patients with precancerous lesions, and 60.7% in patients with superficial gastritis. There were significant differences in the rate of Hp infection among patients with gastric cancer and patients with superficial gastritis（P〈0.05）. The rate of Hp infection rate among people over age 61 was significantly higher than that among people under 60（P〈0.05）. The rate of Hp infection in patients with gastric cancer and lymph node metastasis was significantly higher than that in patients with gastrie cancer and no lymph node metastasis（P〈0.05）. There were no significant differences in the rate of Hp infection among the sexes and among different gastric cancer pathologies, cancer sizes, and depths of invasion （P〉0.05）. Conclusion Hp infection is associated with the development of gastric cancer in the middle of the Hexi Corridor and is related to lymph node metastasis. Hp infection increased with the age in the middle of the Hexi Corridor.