术中电子线照射治疗腹膜后肉瘤的安全性分析

Analysis of the safety of intraoperative electron beam radiotherapy for retroperitoneal sarcoma

目的：分析术中电子线放射治疗腹膜后肉瘤的安全性。方法：选择2008年11月-2010年12月30例腹膜后肉瘤患者行手术联合术中电子线放疗。采用Mobetron1000移动式电子束术中放疗系统，靶区为瘤床及肉眼可见肿瘤，一次给予15C．y或20Gy。8例患者术后又行外照射，剂量50Gy／25F。中位随访时间84-fl（1-17个月）。结果：9例（30．0％）患者出现1-2度胃肠道反应；4例（13．3％）术后出现肠梗阻；10例（33-3％）术后贫血；2例（6．7％）术后腹痛。切口愈合时间未见延迟。结论：术中电子线放疗急性毒副反应较轻，临床安全性高。

Objective： To analyze the safety of intraoperative electron beam radiotherapy （IOERT） for retroperitoneal sar coma. Methods： From Nov 2008 to Dec 2010, 30 patients with retroperitoneal sarcoma received surgical resection and IO ERT. Intraoperative radiotherapy was performed with Mobetron mobile electron accelerator, with a single dose of 15 Gy or 20 Gy. Target included tumor bed and residual tumor. Eight patients received post operative external beam radiotherapy with a dose of 50 Gy/25 F. The median follow up was 8 months （1-17 months ）. Results： Grade 1-2 gastrointestinal side effects were recorded in 9 patients （30.0%） and intestinal obstruction was noted in 4 patients （13.3%）. Ten patients （33.3%） had anemia and 2 （6.7%） had abdominal pain. Delay of healing time was not observed. Conclusion： IOERT is safe for treatment due to its minor toxicity.