开心散治疗轻、中度抑郁症临床观察

Clinical Curative Effects of Kaixin Powder on Depression with Mild or Moderate Degree

目的:观察开心散治疗抑郁症的临床疗效。方法:运用随机数字表法将80例轻、中度抑郁症患者分为治疗组和对照组,其中治疗组40例,用开心散治疗,对照组40例,用氟西汀治疗,疗程均为8周,运用HAMD量表总分减分率、HAMD量表七项因子减分值进行疗效评定。结果:在治疗2周、4周时,治疗组的HAMD减分疗效优于对照组(P<0.05),而两组在治疗6周、8周时HAMD减分疗效相当;在治疗8周时治疗组的临床控制率优于对照组(P<0.05)。治疗组对焦虑躯体化因子、睡眠障碍因子的减分值优于对照组,差异有统计学意义(P<0.05)。结论:开心散是治疗轻、中度抑郁症的安全、有效方剂,值得进一步深入研究。

Objective ：To research clinical curative effects of Kaixin Powder on depression. Methods：Eighty patients suffering from depression with mild or moderate degree were randomly divided into two groups according to a random digits table, Kaixln Powder group and Fluoxetine group, with 40 eases in each group. Patients in the Kalxin Powder group were treated with Kaixin Powder and in the Fluoxetine group with Fluoxetine for 8 weeks. Hamilton rating scale for depression （HAMD） and the rating seole of each factors of 7 - factor HAMD were used to evaluate curative effecton. Results ： After two and four weeks of treatment, Hamilton rating scale, which reflecting the curative effect, was more obvious in Kaixin Powder,with a significant difference （P 〈 0.05 ）. For 6 weeks and 8 weeks treatment, there was not a significant differ- ence between two groups （ P 〉 0.05 ） , but the clinical controlling ratio after 8 weeks treatment was more significant in Kaixin Powder group （ P 〈 0.05 ）. The rating scores of anxiety/somatization and sleep disturbance was more obvious in Kaixin Powder group than another, with a significant difference （ P 〈 0.05 ）. Conclusion ： Kaixin Powder is secure and ef- fective in treating on depression, and, it＇s worth further study.