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TPH2基因与情感障碍关系的元分析研究 被引量：6

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摘要 研究的目的在于探讨色氨酸羟化酶2(TPH2)基因的多态性与情感障碍的关系。本文选取了TPH2基因的4个研究较多的多态性的位点。通过文献检索搜集了15篇有关TPH2与情感障碍的关联研究。元分析研究发现位于TPH2基因的启动区域的多态性位点rs11178997的A等位基因是双向障碍的危险因子。同样靠近5’端的启动子区域rs4570625的G等位基因是抑郁症的危险因素。
作者 何小燕 姚树桥 刘衔华
机构地区 中南大学湘雅二医院医学心理学研究中心
出处 《国际精神病学杂志》 2011年第2期92-97,共6页 Journal Of International Psychiatry
关键词 抑郁症 双相障碍 TPH2基因 元分析
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献15

  • 1Chen C, Glatt S J, Tsuang MT, et al. The tryptophan hydroxylase gene influences risk for bipolar disorder but not major depressive disorder. Bipolar Disorders, 2008 ; 10(7): 816-821.
  • 2Walther DJ, Peter JU, Bashammakh S, et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science, 2003; 299 (5603): 76.
  • 3Sugden D. Comparison of circadian expression of tryptophan hydroxylase isoform mRNAs in the rat pineal gland using real - time PCR. Journal of Neurochemistry, 2003 ; 86 ( 5 ) : 1308 - 1311.
  • 4Zhang X, Gainetdinov RR, Beaulieu JM, et al. Loss - of -function mutation in tryptophan hydmx - ylase- 2 identified in unipolar major depression. Neuron, 2005; 45 (1): 11-16.
  • 5Delorme R, Durand CM, Betancur C, et. al . No human tryptophan hydroxylase- 2 gene R441H mutation in a large cohort of psychiatric patients and control subjects. Society of Biological Psychiatry, 2006; 60 (2): 202 -203.
  • 6Zill P, Baghai TC, Zwanzger P, et al. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Molecular Psychiatry , 2004; 9 (11 ) : 1030- 1036.
  • 7Harvey M , Shink E , Tremblay M , et al. Support for the involvement of TPH2 gene in affective disorders. Molecular Psychiatry, 2004; 9 (11): 980-981.
  • 8Lin YM, Chao SC, Chen TM, et al. Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Arch Gen Psychiatry, 2007; 64 (9) : 1015 -1024.
  • 9Campos SB, Miranda DM, Souza BR, et al. Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior. Journal of Psychiatric Research, 2010 ; 44 (5): 271-274.
  • 10Egger M, Davey SG, Schneider M, et al. Bias in meta - analysis detected by a simple, graphical test. BMJ. 1997; 315 (7109): 629 -634.

同被引文献67

  • 1汪广剑,瞿发林,仲爱芳,卜莹,闫同军.产后抑郁症与雌激素受体β基因的多态性[J].东南国防医药,2013,15(2):177-178. 被引量：10
  • 2Leventhal AM. Sadness,depression,and avoidance behavior[J].Behavior Modification,2008.759-779.
  • 3Oquendo MA,Placidi GP,Malone KM. Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression[J].Archives of General Psychiatry,2003.14-22.
  • 4Zill P,Baghai TC,Zwanzger P. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression[J].Molecular Psychiatry,2004.1030-1036.
  • 5Walitza S,Renner T J,Dempfle A. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder[J].Molecular Psychiatry,2005.1126-1132.
  • 6Scheuch K,Lautenschlager M,Grohmann M. Characterization of a functional promoter polymorphism of the human typtophan hydroxylase 2 gene in serotonergic raphe neurons[J].Biological Psychiatry,2007.1288-1294.
  • 7Cichon S,Winge L,Mattheisen M. Brain-specific tryptophan hydroxylase 2 (TPH2):a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder[J].Human Molecular Genetics,2008.87-97.
  • 8Lin YM,Chao SC,Chen TM. Association of functional polymorphisms of the human typtophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese[J].Archives of General Psychiatry,2007.1015-1024.
  • 9Cao JX, Hu J, Ye XM, et al. Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population [ J 1. Brain Res, 2011,1376 : 1-9.
  • 10McHugh RK, Hofmann SG, Asnaani A, et al. The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review [ J 1. Drug Alcohol Depend, 2010,108 (1-2) : 1-6.

引证文献6

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国际精神病学杂志
2011年 第2期

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