期刊文献+

精神分裂症药效相关转运体及靶受体基因多态性的研究进展 被引量:1

原文传递
导出
摘要 精神分裂症药物治疗的效果因人而异,抗精神病药物代谢通路上相关基因的多态性影响其疗效。本文主要总结了与精神分裂症药物疗效相关的转运体和受体MDR1、DRD2、DRD3、5-HT2AR及5-HT2CR基因的多态性与抗精神病药物疗效关联性研究的进展,并简要分析了出现不一致结果的原因。
出处 《国际精神病学杂志》 2011年第2期114-117,共4页 Journal Of International Psychiatry
  • 相关文献

参考文献14

  • 1Wang JS, Taylor R. Olanzapine Penetration into Brain is Greater in Transgenic Abcbla P - glycoprotein - Deficient Mice than FVB1 (Wild -Type) Animals. Neu ro psychopha rmacology, 2004: 29:551-557.
  • 2KIRCHBAUM KIM, STEFAN IH. Pharmacodynamic consequences of P - glycoprotein dependent pharmacokinetics of risperidone and haloperidol in mice. Behav Brain Res. 2008; 188 (2): 298-303.
  • 3NORIO YF, MANABU S. Association between muhidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients: A preliminary study. Prog Neuropsychopharmacol Biol Psychiatry, 2006; 30 (2): 286-291.
  • 4Alenius M, Wadeliua M, Dahl ML. Gene polymorphism influencing treatment response in psychotic patients in a naturalistic setting. J Psychiatri Res. 2008 ; 42 ( 11 ) : 884 - 893.
  • 5Bozina N, Kuzman MR, Medved V. Associations between MDR1 gene polymorphisms and schizophrenia and therapeutic response to olanzapine in female schizophrenic patients. J Psychiatr Res. 2008 ; 42 (2) : 89 - 97.
  • 6Xing QH, Gao R, Li HF. Polymorphisms of the ABCBI gene are associated with the therapeutic response to risperi- done in Chinese schizophrenia patients. Pharmacogenomics, 2006; 7 (7): 987-993.
  • 7Shen YC, Chen SF, Chen CH, et al. Effects of DRD2/ ANKK1 gene variations and clinical factors on aripiprazoIe ef- ficacy in schizophrenicpatients. J Psychiatric Res. 2009 ; 43 : 600-606.
  • 8Kwon JS, Kim E, Kang DH, et al. TaqlA polymorphism in the dopamine D2 receptor gene as a predictor of Clinical response to aripiprazole. Eur NeuropsychopharmacoIogy, 2008; 18 (12): 897-907.
  • 9Wu S, Xing Q, Gao R. Response to chlorpromazine treatment may be associated with polymorphisms Of the DRD2 gene in Chinese schizophrenic patients. Neuroscience Letters, 2005; 376:1 -4.
  • 10Yamanouchi Y, lwata N, Suzuki T, et al. Effect of DRD2, 5 - HT2A, and COMT genes on antipsychotic re- sponse to risperidone. Pharmacogenomics, 2003 ; 3 : 356 - 361.

同被引文献1

引证文献1

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部