摘要
目的观察替吉奥联合多西紫杉醇治疗晚期胃癌的疗效及不良反应。方法 21例手术后复发的晚期胃癌患者,采用多西紫杉醇60 mg/m^2,第1天静脉输注1小时;替吉奥40mg/m^2,口服,2次/d,连用14天,21天为一周期,2个周期后评价疗效及不良反应。结果 21例患者均可评价,2例完全缓解(CR),8例部分缓解(PR),5例稳定(SD),6例进展(PD)。总有效率(RR)为47.6%,中位疾病进展时间为5个月;其主要不良反应有骨髓抑制、腹泻、口腔黏膜炎、皮肤色素沉着等。结论替吉奥联合多西紫杉醇治疗晚期胃痛疗效好.不良反应能够耐受。
Objective Gio observation combined with doeetaxel for the treatment of advanced gastric cancer and adverse reactions. Methods 21 eases of recurrence after surgery in patients with advanced gastric cancer, with doeetaxe160 mg/ m^2 on day 1 ,intravenous infusion of 1 hour; Gio for 40 mg/m^2 ,oral,bid,used 14 days,21 days for a cycle,evaluated after 2 cycles and adverse reactions. Results 21 patients can be evaluated,2 eases of complete remission（ CR）, 8 cases of partlal remission（ PR）, 5 patients with stable（ SD）, and 6 patients with advanced（PD）. The total effective rate（RR） was 47.6%, the median time to progression was 5 months. The main adverse reactions are bone marrow suppression, diarrhea, oral mucositis, skin pigmentation and so on. Conclusion Gio combined with docetaxal for the treatment of advanced gastric cancer is good, able to withstand adverse.
出处
《中国医学创新》
CAS
2011年第13期48-50,共3页
Medical Innovation of China
