妊娠妇女血清瘦素水平测定及临床意义

Clinical Significance of Detecting the Levels of Serum Leptin in Pregnancy Women

目的:探讨妊娠期妇女血清瘦素水平的临床意义。方法:选取2008年3月至2009年9月间就诊的伴有妊娠期高血压(HDCP)及妊娠期糖尿病(GDM)的患者共210例,其中前者110例,后者100例;另外选取同期正常妊娠妇女210例用以对照。采用放射免疫法测定各组患者血清瘦素水平。结果:HDCP组血清瘦素水平明显高于正常妊娠组,且其水平随HDCP严重程度增加而增加,GDM组患者瘦素水平明显高于正常妊娠组,组间比较差异明显,有统计学意义(P<0.05)。结论:空腹血清瘦素水平增高可见与妊娠期高血压患者和妊娠期糖尿病患者,并在一定程度上反应病情严重程度,可作为诊断和病情评估的指标之一。

Objective：To explore the clinical significance of detecting the level of serum leptin in pregnancy women.Method：We selected 210 pregnancy women with HDCP（110 cases） and with GDM（100 cases） and another 210 normal pregnancy women.Radioimmunoassay was used to test the levels of serum leptin in the patients of two groups.Result：Serum leptin of HDCP group and GDM group were significantly higher than that of normal pregnant women（P〈0.05）.Conclusion：In HDCP women and GDM women,serum leptin which can be used to diagnosis and evaluate the pathogenetic condition were changed greatly and indicated the prognosis.