高压氧对高血压性心脏病左室重构的影响

Effects of Hyperbaric Oxygen on Left Ventricular Reconstruction of Patients with Hypertensive Heart Disease

目的:探讨高压氧对高血压性心脏病左室重构的影响。方法:随机将80例高血压性心脏病患者分为两组,其中40例在常规药物治疗基础上加用高压氧治疗为治疗组,40例应用常规药物治疗为对照组,治疗前后进行彩色多普勒超声检测。随访6个月复合心血管事件发生率。结果:治疗组行高压氧治疗后,室间隔舒张末期厚度(IVSD)、左室后壁舒张末期厚度(LVPWD)、左室心肌重量指数(LVM I)明显降低(P(0.001),与对照组比较有显著性差异(P(0.05)。随访6个月,治疗组发生复合心血管事件较对照组减少且有显著性差异(P(0.05)。结论:高压氧治疗高血压性心脏病能逆转高血压性心脏病左室肥厚(LVH),并减少心血管事件发生率。

Objective：To study the effects of hyperbaric oxygen on left ventricular reconstruction in patients with hypertensive heart disease.Method：80 patients with hypertensive heart disease were randomly divided into treatment group and control group.Conventional therapy was given to the patients of both groups.In addition,hyperbaric oxygen therapy was applied to those in treatment group.After 6 months,Doppler ultrasound recordings were obtained from all patients to determine the diastolic ventricular septum thickness（IVSD）,left ventricular end diastolic wall thickness（LVPWD） and left ventricular mass index（LVMI）.Result：After hyperbaric oxygen therapy,IVSD,LVPWD and LVMI significantly decreased（P﹤0.001） in treatment group,and there’s significant differences between two groups（P ﹤ 0.05）.Follow-up for 6 months,the treatment group occured relatively complex cardiovascular events less and there’s significance difference（P﹤0.05） between two groups.Conclusion：Hyperbaric oxygen therapy could reverse the hypertensive heart disease in patients with left ventricular hypertrophy（LVH）,and reduce the incidence of cardiovascular events.