176株金黄色葡萄球菌感染的临床分布及耐药性分析

Clinical Distribution and Resistance Analysis of 176 Strains Staphylococcus Aureus Infection

目的:了解医院近3年金黄色葡萄球菌感染分布及耐药情况。方法:对176株临床分离的标本分布和科室分布情况进行调查,用纸片扩散法进行药敏试验并对结果进行分析。结果:176株金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)125株,占71.0%,MRSA对青霉素G100%耐药,对万古霉素、替考拉宁、利奈唑烷100%敏感,对氯霉素耐药率为18.4%,复方新诺明为12.8%,对大环内酯类、氨基糖苷类、克林霉素等抗菌药物耐药率均较大(77.6-94.4%),且存在多重耐药,MR-SA耐药率显著高于MSSA。结论:金黄色葡萄球菌对常用抗菌药物显示多重耐药,特别对于MRSA应有针对性加强监测与控制,根据药敏试验合理换用相应抗菌药物以减缓VISA、VRSA的出现。

Objective：To explore the infectious distribution and resistance profile of staphylococcus aureus infection occurred in our hospital in the recent three years.Method：Investigations of the distribution situation of specimen and department were made to the 176 strains bacteria isolated from our hospital,whose drug-susceptibilities were performed by Kirby-Bauer method and performed analysis of results.Result：Of 176 strains of isolated staphylococcus aureus,125 strains were MRSA,accouinting for 71.0%.100% of MRSA were resistant to penicillin G but susceptible to vancomycin,vancomycin and linezolid.Resistance of MRSA to chloramphenicol,trimethoprim were 18.4%,12.8%,respectively.The resistance rate to macrolides,aminoglycoside,clindamycin was even higher（77.6%-94.4%） and there was a multiple resistance.The resistance rate of MRSA was significantly higher than that of MSSA.Conclusion：Staphylococcus aureus,especially MRSA,are multidrug-resistant to commonly used antimicrobial agents.Their drug resistance shoud be monitored and controlled closely.The therapy towards infection of staphylococcus aureus should be applied reasonably according to the drug sensitive test so as to slow down the emergence of VISA and VRSA.