沙美特罗替卡松粉治疗慢性阻塞性肺疾病缓解期的应用研究

Study on the effect of seretide on lung function during the stable stage of chronic obstructive pulmonary disease

目的 探讨舒利迭对缓解期慢性阻塞性肺疾病（COPD）患者肺功能和生存质量的影响.方法 将80例缓解期COPD患者随机分为观察组和对照组,每组各40例.两组患者均给予基础治疗,对照组给予口服沐舒坦,观察组给予舒利迭,于治疗前、治疗后3个月行肺功能检查、生存质量问卷调查,观察治疗期间病情急性加重次数.结果 两组患者肺功能、生存质量均有改善,观察组改善程度大于对照组,差异有统计学意义（P＜0.05）;观察组治疗期间急性加重次数明显少于对照组（P＜0.05）.结论 舒利迭能改善COPD缓解期患者的肺功能和生存质量,减少急性加重次数,值得临床推广应用.

Objective To explore the effect of seretide on lung function and survival quality in patients with chronic obstructive pulmonary disease （COPD） in catabasis. Methods 80 cases patients were divided into the intervention group （ 40 cases） and control group （40 cases）. The patients took basic treatment, the patients in the control group were treated with ambroxol, the patients in the intervention group were treated with seretide. Lung function, survival quality and the frequencies of acute exacerbation were evaluated before and after three - month treatment. Results Lung function and survival quality of all patients improved six - month after the therapy, there were significant differences （ P 〈 0. 05 ）. Compared with control group, the frequencies of acute exacerbation of intervention group were reduced more significantly （ P 〈 0. 05 ）. Conclusion Seretide could significantly improve the lung function and survival quality, reduce the frequencies of acute exacerbation of patients with COPD in catabasis, and hence is worthy of being recommended in clinical practice.