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中药新药研发的新模式 被引量：3

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摘要 20年来批准生产的中药新药,低水平重复十分严重,品种数量的增加远远超过了质量与水平的提高,创新发展不足。提高疗效、提高安全性、提高质量没有受到应有的重视,加之制药企业急功近利,要求低投入、低风险、高回报、快回报,因而低水平重复成为中药发展的主流,而创新发展陷入举步维艰的困境。例如20年来申报注册的21086种中药中,真正属于新药的品种2963种（占14.2%）,而仿制药5285种（占25.9%）,改变剂型、规格或适应症的变相仿制药达11727件（占58.2%）,
作者 麦景标 冯俭 孙川 刘晨昕
机构地区 成都中医药大学药学院
出处 《湖北中医杂志》 2011年第5期73-74,共2页 Hubei Journal of Traditional Chinese Medicine
关键词 中药指纹图谱 思路与方法 新药研发 中药复方
分类号 R28 [医药卫生—中药学]
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二级参考文献10

  • 1罗国安,梁琼麟,张荣利,王义明,刘清飞,胡坪.化学物质组学与中药方剂研究——兼析清开灵复方物质基础研究[J].世界科学技术-中医药现代化,2006,8(1):6-15. 被引量：64
  • 2赵艳峰,叶能胜,张荣利,冯雪,罗国安,王义明.中国小型猪心肌梗死模型的比较蛋白质组学研究[J].高等学校化学学报,2006,27(8):1467-1471. 被引量：7
  • 3Hood L.Systems biology:new opportunities arising from genomics,proteomics and beyond.Experimental Hematology,1998,26 (8):681 ～ 681.
  • 4Ideker T,Galitski T,Hood L.A new approach to decoding life:systems biology.Annual Review of Genomics and Human Genetics,2001,2:343～ 372.
  • 5Weston AD,Hood L.Systems biology,proteomics,and the future of health care toward predictive preventative,and personalized medicine.Journal of Proteome Research,2004,3 (2:179 ～ 196.
  • 6Hood L.Integrative systems biology:Genomics,proteomics,and computation.Abstracts of Papers of the American Chemical Society,2002,224,045-BIOT Part 1:U205-U205.
  • 7Nicholson JK,Wilson ID.Understanding 'global'systems biology:metabonomics and the continuum of metabolism.Nature Reviews Drug Discovery,2003,2 (8):668 ～ 676.
  • 8Fidock DA,Rosenthal PJ,Croft SL,et.al.Antimalarial drug discovery:efficacy models for compound screening.Nature Reviews Drug Discovery,2004,3 (6):509 ～ 520.
  • 9Handelsman J,Rondon MR,Brady SF,et.al.Molecular biological access to the chemistry of unknown soil microbes:A new frontier for natural products.Chemistry & Biology,1998,5 (10):R245 ～ R249.
  • 10夏建飞,梁琼麟,胡坪,王义明,罗国安.代谢组学研究策略与方法的新进展[J].分析化学,2009,37(1):136-143. 被引量：63

共引文献105

同被引文献46

  • 1李野,杨悦.中药研发的路径选择[J].中国药房,2005,16(11):815-816. 被引量：6
  • 2Waki I,Kyo H,Yasuda M. Effects of a hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals[J].Journal of Pharmacobio-Dynamics,1982,(08):547-554.
  • 3Hwang JT,Lee MS,Kim HJ. Antiobesity effect of ginsennside Rg3 involves the AMPK and PPAR-gamma signal pathways[J].Phytotherapy Research,2009,(02):262-266.doi:10.1002/ptr.2606.
  • 4LeeWK,Kao ST,LiuIM. Ginsenoside Rh2 isoneofthe active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats[J].Hormone and Metabolic Research,2007,(05):347-354.doi:10.1055/s-2007-976537.
  • 5Lee WK,Kao ST,Liu IM. Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats[J].Clinical and Experimental Pharmacology and Physiology,2006,(1-2):27-32.
  • 6KimJJ,Xiao H,TanY. The effects and mechanism ofsaponins of Panax notoginseng on glucose metabolism in 3T3-L1 cells[J].American Journal of Chinese Medicine,2009,(06):1179-1189.
  • 7Liu Z,Wang LJ,Li X. Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice[J].Phytotherapy Research,2009,(10):1426-1430.
  • 8Ni HX,Yu N J,Yang XH. The study of ginsenoside on PPARgamma expression of mononuclear macrophage in type 2 diabetes[J].Molecular Biology Reports,2010,(06):2975-2979.
  • 9Yuan HD,Kim SJ,Chung SH. Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways[J].Metabolism-Clinical and Experimental,2011,(01):43-51.
  • 10Kim K,Kim DH,Kim HY. Compound K protects MIN6N8 pancreatic beta-cells against palmitate-induced apoptosis through modulating SAPK/JNK activation[J].Cell Biology International,2009,(01):75-80.

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湖北中医杂志
2011年 第5期

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