产蛋鸡铜中毒的临床病理学研究

Clinicopathological Study of Layer Copper Poisoning

武威市某种鸡场种鸡日粮中铜含量的质量分数为（下同）11.90×10-4,锌含量为3.90×10-4,连喂4 d,致使鸡发生铜中毒。受害鸡群产蛋率降至33.15%~71.42%,死亡率达25.33%~25.75%;种蛋孵化率为48.40%;雏鸡生长缓慢,发育不良,一月龄死亡率66.47%。临床检验与健康鸡比较红细胞0.05〉P〉0.01,血红蛋白、红细胞比容、嗜中性粒细胞、淋巴细胞P〈0.01,血清萄萄糖P〈0.01,肝铜值P〈0.01。病理学检验结果表明：肝脏肿大、坏死、出血,实质细胞严重变性;肾脏肿大,出血,肾小管上皮细胞变性;肌胃角质膜和盲肠粘连发生溃疡、出血。经用解毒、保肝、利胆、止血的中西药治疗,35 d后病鸡群恢复正常。

The chronic copper poisoning experiment was carried out in chicken farm Wuwei city.The chicken daily diet copper percent is 11.90×10-4.and zinc is 3.90×10-4.After 4 days continuous feeding,chicken poisoned by copper.Laying rate of suffering chicken flock reduced to 33.15%~71.42%,the mortality rate was 25.33%~25.75%,hatchability reduced to 48.40%.Young chicken grew slowly and abnormally,mortality among one month was 66.47%.Clinical test showed that there was difference in erythrocyte concentration compared with the healthy chicken（P0.05）,significance differences in hemoglobin,hematocrit,neutrophil granulocyte,lymphocyte,serum glucose,liver copper compared with the healthy chicken（P0.01）.Pathological examination results showed that liver enlargement,necrosis and hemorrhage,parenchyma cell denaturalization,kidney enlargement,necrosis,epithelial cell denaturation,gizzard membranous and cecum adhesion,ulcer and hemorrhage.After the treatment of Chinese and Western medicines such as antidoted the poison,protecting liver,cholagogue function and hemostasis,chicken flock returned to normal after 35 days.