肺功能检测对儿童喘息性疾病的临床相关性研究

Clinical relevance of lung function tests for wheezing children

目的探讨肺功能检测对儿童喘息性疾病的临床意义。方法采用法国迪尔肺功能测定系统分别对90例喘息性疾病患儿发作期、缓解期和48例正常健康儿童进行肺功能测定及临床分析。结果喘息性疾病患儿发作期肺功能指标FVC、FEV1、PEF、FEF25、FEF50、均明显低于预计值,气道阻抗RINT值明显增高与缓解期和对照组比较P<0.05,说明喘息性疾病患儿存在气道高反应和气流受限,肺功能减损程度与病情及病程一致。结论儿童肺功能检测客观而重复性强,与临床相关性好,动态观察可早期识别喘息性疾病并发现哮喘,有利于早期干预及时治疗,特别对年幼儿哮喘意义重大。

Objective To investigate the clinical relevance of lung function tests for children with wheeze.Methods Compare lung function of wheezing patients（n=90） with normal children（n=48）.Results Lung function parameters（FVC,FEV1,PEF,FEF25,and FEF50） of wheezing children at attaching-phase were much lower than expected values.RINT was significant higher than patients at remission phase and control group（P〈0.05）,it proved that there was airway hyper-responsiveness and airway restriction.Conclusion Lung function tests provide evidences to diagnose wheezing diseases and asthma by dynamic observation of lung function.