吡格列酮联合胰岛素治疗2型糖尿病对患者血清脂联素的影响被引量：1

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摘要目的探讨吡格列酮联合胰岛素治疗2型糖尿病(T2DM)对患者血清脂联素水平影响。方法对我院60例应用磺脲类和双胍类药物治疗血糖控制不佳的2型糖尿病患者随机分为治疗组30例及对照组30例。治疗组予吡格列酮联合门冬胰岛素30治疗,对照组予门冬胰岛素30治疗,疗程均为12周。观察两组患者治疗前后的血清脂联素、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗水平(IR)、胰岛素用量的变化。结果治疗组与对照组比较血清脂联素水平显著升高(P<0.05),且治疗组胰岛素抵抗水平(IR)水平明显下降(P<0.05),治疗组胰岛素用量低于对照组(P<0.05)。结论我院对于磺脲类和双胍类药物治疗不佳的2型糖尿病患者采用吡格列酮联合门冬胰岛素30治疗,可提高2型糖尿病患者血清脂联素水平,减少胰岛素用量。

作者魏文华

机构地区汕头市金平区人民医院

出处《海南医学》 CAS 2011年第10期126-127,共2页 Hainan Medical Journal

关键词脂联素吡格列酮胰岛素用量 2型糖尿病胰岛素抵抗空腹血糖糖化血红蛋白

分类号 R587.1 [医药卫生—内分泌]

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二级参考文献7

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