消栓宁心汤治疗急性心源性脑栓塞临床研究

Clinical Research of Xiaoshuan Ningxin Decoction in Treating Acute Cardiogenic Cerebral Embolism

目的:探讨中药消栓宁心汤治疗急性脑栓塞临床疗效。方法:将92例患者随机分为治疗组及对照组,治疗组在应用肠溶阿斯匹林、依达拉奉等西药基础上加用自拟消栓宁心汤治疗,对照组仅用西药治疗,14d后对两组患者按《欧洲脑卒中评分》标准(ESS)评分来判断疗效。结果:治疗组有效率86.9%,明显优于对照组有效率的65.2%,差异有显著性(P<0.01),且在治疗过程中治疗组发生死亡、急性心功能不全和出血性梗死的比例明显低于对照组。结论:中药治疗心源性脑栓塞既能降低死亡率,减轻神经功能缺损,又能减少出血性脑梗死及心力衰竭等并发症的发生,是一种安全、有效的治疗方法。

Objective ：To observe the clinical efficacy of Xiaoshuan Ningxin Decoction. Methods ：92 patients were randomly divided into treatment group and control group. The treatment group were given self - made Xiaoshuan Ningxin Decoction on the basis of other west- ern medicines such as enteric - coated aspirin and edaravone while the control group were only given western medicine treatment. 14 d later,patients in the two groups were evaluated to determine efficacy according to ＂European Stroke Score＂ standard （ESS）. Results： The total effective rate was 86.9% ,which was significantly better than the control group （65.2%） and the difference was significant （P 〈 0.01 ） ;and the incidence of death, acute cardiac insufficiency and hemorrhagic infarction in the treatment group during the thera- peutic process was significantly lower than the control group. Conclusion：The application of Chinese medicinals in the treatment of car- diogenie cerebral embolism not only reduces mortality and neurological deficits as well as complications such as hemorrhagic infarction and heart failure ete,which is a safe and effective treatment.