空腹血糖调节受损伴颈动脉粥样硬化与老年认知功能障碍的相关性研究

Correlation of carotid atherosclerosis combined with impaired fasting glycaemia and cognitive impairment in elderly population

目的探讨空腹血糖调节受损(impaired fasting glycaemia,IFG)伴颈动脉粥样硬化与老年人认知功能障碍的关系。方法我院门诊就诊或住院的老年患者169例,采用简易智能状态量表检查,根据认知情况分为认知功能障碍组(81例)及正常认知功能组,运用多因素分析IFG合并颈动脉粥样硬化是否与老年人认知功能相关。结果认知功能障碍组年龄(P=0.000)、女性(P=0.040)、颈动脉粥样硬化合并IFG(P=0.003)、高血压(P=0.002)与正常认知功能组相比,差异有统计学意义;logistic回归显示仅颈动脉粥样硬化合并IFG(P=0.029)、年龄(P=0.000)及高血压(P=0.049)与老年人认知功能障碍独立相关。结论与年龄及高血压等因素一样,颈动脉粥样硬化合并IFG是老年人认知功能障碍的独立的危险因素。

Objective To assess the relationship between carotid atherosclerosis combined with impaired fasting glycaemia and cognitive impairment.Methods A total of 169 patients were included.Mini-Mental State Examination was used to evaluate the cognitive function of elderly population,and then the patients were divided into cognitive impairment group and normal cognitive function group.Multivariate analysis was used to assess the relationship between carotid atherosclerosis combined with impaired fasting glycaemia and cognitive impairment.Results Univariate analysis suggested that age（P=0.000）,female（P=0.040）,carotid atherosclerosis combined with impaired fasting glycaemia（P=0.003）and hypertension（P=0.002）between the two groups had significant difference,and logistic regression analysis demonstrated carotid atherosclerosis combined with impaired fasting glycaemia（P=0.029）,age（P=0.000）and hypertension（P=0.049）might be independent risk factors of cognitive impairment in elderly population.Conclusion Carotid atherosclerosis combined with impaired fasting glycaemia may be an independent risk factor as age and hypertension.