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低氧诱导因子及其他相关因子与缺血性卒中发病机制的研究进展 被引量:9

Progress in pathogenesis of cerebral arterial thrombosis and hypoxia indacible and other related facors
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摘要 低氧是脑血管疾病尤其是缺血性脑卒中过程中一个重要的病理生理因素,是卒中过程中低氧应答时基因表达和恢复内环境平衡的调节中心。低氧诱导因子(HIF-1)对缺血坏死后新生血管的形成和低氧诱导的细胞凋亡过程都是非常关键的因素。调控HIF-1水平可能为缺血性疾病的治疗开辟新的途径。
作者 陈林 罗永杰
出处 《实用医院临床杂志》 2011年第3期155-158,共4页 Practical Journal of Clinical Medicine
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  • 1Semenza GL,Wang GL.A nuclear factor induced by hypoxia via de novo protein synthesis birds to the human erythopoitin gene enhancer at a site required for transcripticnal activation[J].MD cell Bio1,1992,12 (12):5447-5454.
  • 2Pugh CW,Oroarke JF,Nagao M,et al.Activation of hypoxia-inducible-factor-1:difinitionf of regulatory dormains withint he a subunit[J].J Biol,2006,272 (17):1205-1214.
  • 3Sutter CH,Laughner E,Semenza GL.HIF-1α Protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations[J].Proc Nat 1 Acad,2007,97 (9):4748-4753.
  • 4Kal1io PJ,Wjllson WJ,0'Briens,et al.Regulation of the hypox-ia-inducible transcripticn factor la by the ubiquition proteasome pathway[J].J Boil chem,2005,274 (10):6519-6525.
  • 5Jung YJ,Isaacs JS,Lee S,et al.IL-1 beta-mediated up-regulation of HIF-1alpha via an NF-kappaB/COX-2 pathway identifiesHIF-1 as a critical link between inflammation and oncogenesis[J].FASEB J,2003,17(14):2115-2117.
  • 6Nanka O,Valasek P,Dvorakova M,et al.Experimental hypoxia and embryonic angiogenesis[J].Developmental Dynamics,2006,235 (3):723-733.
  • 7Matsuda T,Abe T.Hypoxia inducable factor-1aDNA induced angiogenesis in a rat cerebral inchemia model[J].Neurol Res,2005,27(5):503-508.
  • 8Semenza GL,Doughman Y.Partial rescue of defects in Cited-deficient embryos by HIF-1 alpha heterozygosity[J].Dev Biol,2007,301 (1):130-140.
  • 9Maiese K.Erythropoietin in the brain can the promise to protect be fulfilled[J].Trends Pharmacol Sci,2004,25(11):577-583.
  • 10Arishima,Setoguchi Y,Yamaura,et al.Preventive effect of erythropoietin on spinal cord cell apoptosis following acute traumatic injury in rats[J].Spine,2006,31 (21):2432-2438.

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