期刊文献+

血管紧张素Ⅱ2型受体在心血管系统的研究进展 被引量:3

下载PDF
导出
摘要 肾素一血管紧张素系统(RAS)是心血管活动重要的体液调节系统,在维持水、电解质平衡及调节血压中起着关键作用。血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)是该系统中最重要的介质,通过与其特异性受体结合而产生相应的生理效应。在心血管系统中AngⅡ受体主要包括AT1R和AT2R两种亚型。
作者 文静 曾晓荣
出处 《西南军医》 2011年第3期493-496,共4页 Journal of Military Surgeon in Southwest China
  • 相关文献

参考文献29

  • 1Utsunomiya H, Nakamura M, Kakudo K ,el al. Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT, gene--deleted mice [ J ]. Regul Pept, 2005,126 ( 3 ) : 155 - 161.
  • 2Savola C, Schiffrin EL Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions [ J ]. Clin Sci (Lond) , 2007,112:375 - 384.
  • 3Warnecke C, Mugrauer P, Surdcr D, et al. Intmnic ANG II type 2 receptor gene polymorphism 1675 G/A modulates receptor protein ex- pression but not mRNA splicing [ J]. Am J Physiol Regal Integr Comp Physio1,2005,289 (6) : 1729 - 1735.
  • 4Alfakih K,Maqbool A,Sivananthan M . etal. Left ventricle mas8 index and the common, functional. X -linked angiotensin II type -2 receptor gene polymorphism( - 1332 G/A)in patients with systemic hypertension[J].Hypertension,2004,43 (6) :1189 - 1194.
  • 5Katada J, Majima M. AT (2) receptor - dependent vasedilation is mediated by activation of vascular kinin generation under flow conditions[ J]. Br J Pharmaco1,2002,136:484 -491.
  • 6Zhu L, Carretero OA, et al. Role of prolylearboxypeptidase in angiotensin II type 2 receptor - mediated bradykinin release in mouse core- nary artery endothelial cells [ J ]. Hypertension , 2010 , 56 ( 3 ) : 384 - 390.
  • 7AbdAlla S, Lother H, Abdel - tawab AM, Quitterer U. The tmgiotensin II AT2 receptor is an AT1 receptor antagonist [ J ] . J Biol Chem, 2001,276:39721 - 6.
  • 8Widdop RE, Matrougui K, Levy BI, Hem-ion D. AT2 receptor- mediated relaxation is preserved after long - term AT1 receptor blockade [ J ]. Hypertension, 2002,40 : 516 - 20.
  • 9Savoia C, Tabct F, Yao G, Schiffrin EL, Touyz RM. Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle calls: role in angiotensin II - induced vasodilation in stroke - prone spontaneously hypertensive rats [ J ]. J Hypertens, 2005,23 : 1037 - 45.
  • 10Savoia C, Touyz RM, Volpe M, Schiffrin EL Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients [J]. Hypertension,2007,49:341 -6.

同被引文献8

引证文献3

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部