摘要
目的观察甘草酸二胺注射液对抗结核药所致肝损害的预防和治疗效果。方法将156例继发型肺结核住院患者随机分为观察组和对照组,各78例。两组均以2HRZE/4HR方案抗结核治疗,观察组于强化期加用甘草酸二胺注射液。治疗30 d后评定疗效。结果观察组发生可逆性中度转氨酶增高7例(8.97%),对照组发生可逆性中度转氨酶增高25例(32.05%),两组比较有统计学意义(P<0.05)。30 d后对照组加用甘草酸二胺注射液,肝功恢复率92%。结论抗结核药物易发生药物性肝损害,甘草酸二胺注射液对药物性肝损害有预防和治疗作用。
Objective To observe the therapeutic effect of diamine glycyrrhizinate on hepatic lesions caused by antiuberculotics. Methods 156 cases were randomly divided into two groups, and both groups adopted 2HRE/ 4HR therapy. Diamine glycyrrhizinate was added to the observation group. Results After 30 clays of treatment, 7 cases（8.9 % ） in the observation group showed the increase in reversible moderate transaminase, while 25 eases （32%） in the control group（ P 〈0.05）. The reversion rate of hepatic function in the contrast group was 92% after diamine glycyrrhizinate was added. Conclusion Patients treated with antiuberculotics are prone to hepatic lesions. Diamine glycyrrhizinate has preventive and therapeutic effects on pharmacologic hepatic lesions.
出处
《山东医学高等专科学校学报》
2011年第2期125-126,共2页
Journal of Shandong Medical College
关键词
肺结核
甘草酸二胺注射液
转氨酶
Tuberculosis
Diamine glycyrrhizinate
Transaminase
