黄葵胶囊对慢性肾脏病患者血清Cystatin C、hs-CRP的影响

Influence of Huangkui capsule on serum cystatin C and high sensitive C-reactive protein in chronic kidney disease patients

目的:观察黄葵胶囊对慢性肾脏病(CKD)患者血清半胱氨酸蛋白酶抑制剂C(Cystatin C)、超敏C反应蛋白(hs-CRP)的影响。方法:将60例明确诊断为CKD的患者随机分为对照组(30例)和治疗组(30例),同时选择20名健康成人作为正常对照组,在基础治疗上加用黄葵胶囊每天3次,每次5粒口服,治疗前、后8周分别检测Cystatin C、hs-CRP、肌酐(Scr)及尿素氮(BUN)。结果:CKD患者血Cystatin C、hs-CRP、Scr及BUN较正常对照组明显增高(P<0.05),常规治疗8周后其CystatinC、hs-CRP、Scr及BUN均有所降低,但差异无统计学意义(P﹥0.05),而加用黄葵胶囊治疗后其Cystatin C、hs-CRP、Scr及BUN明显降低(P<0.05);Cystatin C与GFR呈负相关,与hs-CRP呈正相关。结论:黄葵胶囊可改善早期CKD患者的肾功能和炎症状态,有利于延缓CKD的进展。

Objective：To observe the influence of Huangkui capsule on serum cystatin C and high sensitive C-reactive（hs-CRP） protein in chronic kidney disease patients（CKD）.Methods：Sixty cases CKD patients were randomly divided into two groups,control group（30 cases） and treatment group（treated with Huangkui capsules,30 cases）.Meanwhile,20 healthy adults were taken as the normal control.The blood concentrations of cystatin C,hs-CRP,Scr and BUN were determined.Results：The level of cystatin C,hs-CRP,Scr and BUN in all CKD patients were significantly higher than those in the normal control（P0.05）,the level of cystatin C,hs-CRP,Scr and BUN decreased after 8 weeks of conventional treatment（P﹥0.05）,while those significantly decreased addition of huangkui capsule treatment（P0.05）;Cystatin C and GFR were negatively correlated,but Cystatin C was positively correlated with hs-CRP.Conclusion：The renal function and inflammation can be alleviated by huangkui capsule in early CKD patients,which could be slowed the progression of CKD.