摘要
吸入麻醉药广泛应用于各种手术的临床麻醉,其神经毒性一直是麻醉学领域的研究热点。近年研究发现,接受吸入性麻醉的患者术后会出现细胞凋亡、神经损伤。尤其是处于发育期的婴幼儿和大脑结构发生退行性变的老年人,对神经毒性物质异常敏感,暴露于吸入麻醉药后,可出现记忆、认知功能障碍。这种现象的产生可能与吸入麻醉药导致的海马神经元的凋亡、氨酪酸受体活性增强以及脑代谢改变相关。现就吸入麻醉药的神经毒性作用及其机制予以综述。
Inhalational anesthetics have been widely used in clinical anesthesia for a wide range of surgeries.The neurotoxicities of inhalational anesthetics have been a research hotspot in anesthesiology.It has shown that patients receiving inhalational anesthetics are likely to be complicated with postoperative cell apoptosis and neural injuries.Of note,developing infants and aged patients with cerebral degeneration are more prone to neurotoxicities of inhalational anesthetics,exhibiting memory and cognitive dysfunction.This may be associated with hippocampal cell apoptosis,activated GABA receptor,and cerebral metabolism alteration.This article reviews the neurotoxicities and potential mechanisms of inhalational anesthetics.
出处
《医学综述》
2011年第9期1383-1386,共4页
Medical Recapitulate
关键词
吸入麻醉药
经毒性作用
作用机制
Inhalational anesthetics
Neurotoxicity
Mechanisms
