超重及肥胖人群血清瘦素、脂联素和肿瘤坏死因子α水平的变化及其影响因素

The Variations in Serum Leptin,Adiponectin and TNF-α among Over-weighted and Obese Subjects

目的探讨超重及肥胖人群中,血清脂联素、瘦素和肿瘤坏死因子α(TNF-α)水平及其影响因素。方法 52例正常体质量者和36例超重及肥胖人群,检测血糖、血脂、胰岛素、C肽、肿瘤坏死因子α、瘦素、脂联素。结果与正常体质量人群相比,超重及肥胖人群中血清瘦素水平升高(P<0.01),并与体质量指数正相关(r=0.474,P<0.01),体质量指数和女性是血清瘦素水平的独立影响因素。结论在超重及肥胖人群中,血清瘦素水平增高,并与体质量指数和女性相关。

Objectives To study the serum levels of leptin,adiponectin and TNF-α in over-weighted and obese subjects.Methods Fifty-two normal-weighted and 36 over-weighted/obese subjects were enrolled to collect fasting blood samples for the measurements of plasma glucose,plasma lipids,insulin,C-peptide,TNF-α,leptin,and adiponectin.Results The concentration of leptin wassignificantly higher in over-weighted/obese subjects than that in normal-weight subjects（P0.01）,The Pearson＇s correlation analysis showed that serum leptin concentration was positively correlated with body mass index（r=0.474,P0.01） in over-weighted/obese subjects.The multiple regression analysis showed that body mass index and female were independent factors of serum leptin level in over-weighted/obese subjects.Conclusions The concentrations of leptin are higher and body mass index and female are two independent factors of serum leptin in over-weighted and obese subjects.