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子痫前期-子痫患者TM及IL-6水平变化及意义 被引量:4

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摘要 目的探讨子痫前期-子痫患者血栓调节蛋白(TM)和血清白介素-6(IL-6)水平变化及其之间的相关性。方法选择子痫前期-子痫患者100例,分为子痫前期组50例,子痫组50例,选择同期正常妊娠女性30例为对照组。采用酶联免疫吸附试验(ELISA)方法测定TM和IL-6水平。结果 (1)子痫前期组和子痫组TM和IL-6水平较对照组明显升高(P<0.01),且子痫组TM和IL-6水平较子痫前期组明显升高,差异有统计学意义(P<0.01)。(2)相关分析显示TM和IL-6呈明显正相关(r=0.762,P=0.001)。结论 TM和IL-6与疾病的严重程度密切相关;TM和IL-6在子痫前期-子痫发病中起协同作用。
出处 《河北医药》 CAS 2011年第9期1327-1328,共2页 Hebei Medical Journal
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  • 1Roberts JM, Gammill HS. Preeclampsia: Recent insights. Hypertension, 2005,46 : 1243 - 1249.
  • 2Zhang J,Meikle S,Trumble A. Severe maternal morbidity associated with hypertensive disorders in pregnancy in the United States. Hypertens Pregnancy,2003,22:203-212.
  • 3Swellam M, Samy N, Wahab SA, et al. Emerging role of endothelial and inflammatory markers in preeclampsia. Disease Markers, 2009,26 : 127- 133.
  • 4Kocyigit Y, Atamer Y, Atamer A, et al. Changes in serum levels of leptin, cytokines and lipoprotein in preeclamptic and normotensive pregnant women. Gynecol Endocrinol,2004,19:267 -273.
  • 5Roberts JM, Lain KY. Recent Insights into the Pathogenesis of Pre-eclampsia. Placenta,2002,23:359-372.
  • 6应淑琴,单江,徐耕,陈安,卢兴国.经皮冠状动脉腔内成形术前后冠心病患者血小板、内皮功能和纤溶活性的变化及其临床意义[J].中华血液学杂志,2001,22(3):155-156. 被引量:10
  • 7张爱华,孙达春,李小亮,吴红.大肠癌患者血小板和内皮细胞的功能及临床意义[J].中华消化杂志,2004,24(2):109-110. 被引量:15
  • 8Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost ,2003,29 : 125-130.
  • 9Nadar SK, A1 Yemeni E, Blann AD, et al. Thrombomodulin, yon Will- brand factor and E-selectin as plasma markers of endothelial damage/ dysfunction and activation in pregnancy induced hypertension. Thromb Res,2004,113 : 123-128.
  • 10Takacs P, Green KL, Nikaeo A, et al. Increased vascular endothelial cell production of interleukin-6 in severe preeelampsia. Am J Obstet and Gynecol,2003,188:740-744.

二级参考文献9

共引文献23

同被引文献40

  • 1张周良,李斌.实验性家兔高脂血症对体外血栓形成影响[J].中国血液流变学杂志,2008,18(1):138-139. 被引量:2
  • 2冯亚玲,周昌菊,薛敏.膜联蛋白V在子痫前期蜕膜组织中的表达及其意义[J].南方医科大学学报,2009,29(7):1438-1441. 被引量:5
  • 3杨谨.过敏性紫癜患儿血浆中血栓调节蛋白含量与蛋白C活性的测定及意义[J].实用医学杂志,2007,23(12):1938-1938. 被引量:4
  • 4丰有吉,沈铿.妇产科学[M].2版.北京:人民卫生出版社,2010:325.
  • 5李红艳,田文华,张桂侠,李静,魏力强,张新利.超重及肥胖者血浆游离脂肪酸浓度与动态血压的关系[J].心血管康复医学杂志,2007,16(4):319-321. 被引量:5
  • 6Crispi F, Llurba E,Domlnguez C, et a l. Predictive value of angiogenic factors and uterine artery Doppler for early-versus late-onsetpre--eelampsia and intrauterine growth restriction [J]. Ultrasound Obstet Gynecol, 2008,31(3):303-309.
  • 7Sek izaw a A, Pu rwosunu Y, Yosh imu ra S, et al. PP13 mRNA express ion in trophob lasts from preeelam p tie plaeentas[J] . Rep rodSe,i ,2009, 16( 4 ) : 408-413.
  • 8Than N, Abdul Rahman O, Magenheim R, et al. Placental protein 13(galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm preeclampsia and HELLP syndrome[J]. Virchows Arch, 2008,453 (4) :387-400.
  • 9Hellgren M. Hemostasis during normal pregnancy and puerperium [ J ]. Semin Thromb Hemost,2003,29 : 125 - 130.
  • 10Hayashi M, Inoue T, Hoshimoto K, et al. Characterization of five marker levels of the hemostatic system and endothelial status in norm otensire pregnancy and preeclampsia [ J ]. Eur Jh Aem Atol, 2002,69 : 297 302.

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