1,4-二(氯乙酰基)哌嗪的合成

Synthesis of 1,4bis(chloroacetyl)piperazine

以无水哌嗪和氯乙酰氯为主要起始原料,无水碳酸钠为缚酸剂,水为溶剂,经酰化反应得到1,4-二(氯乙酰基)哌嗪,并对反应的工艺参数进行了优化.最佳反应条件是:n(无水哌嗪)∶n(氯乙酰氯)=1∶2.2,反应温度-6℃,反应60 min,产品收率为83.9%,经1HNMR和MS分析确定产品结构与目标产物相符.

1,4-bis（chloroacetyl）piperazine was prepared from anhydrous piperazine and chloroacetyl chloride using water as solvent in the presence of anhydrous sodium carbonate.Technological parameters involved in this reaction were optimized.Under the optimized conditions：the molar ratio of anhydrous piperazine and chloroacetyl chloride was 1∶2.2,reaction temperature-6 ℃,reaction time 60 min,the yield counting with anhydrous piperazine was 83.9 %.The product structure was conformed to target product through1HNMR and MS analysis and determination.