腱鞘巨细胞瘤92例临床及病理分析

The Clinical and Pathological Analysis of Giant Cell Tumor of Tendon Sheath(A Report of 92 Cases)

目的分析腱鞘巨细胞瘤的临床病理特点、探讨手术治疗方式及预后情况。方法回顾性分析我院2000～2010年收治的92例的临床资料,分析临床及病理组织学特点。结果本组高发年龄段为31～50岁;手部为高发部位,表现为早期局部肿物。肿瘤平均直径1.36 cm,由单核细胞及数量不等的多核巨细胞组成,其中29例瘤细胞生长活跃,6例易见核分裂相。所有病例均行单纯肿瘤切除术,核分裂相活跃者行局部扩大切除。术后随访1～118个月,15例失访,9例复发。结论腱鞘巨细胞瘤是常见软组织良性肿瘤,确诊依据病理形态学检查。确诊后宜行局部切除治疗。

Objective To analyze the clinical and pathological characteristics of giant cell tumor of tendon sheath（GCTTS） , and to study the surgical treatment and prognosis of the disease. Methods The clinical data of 92 cases of GCTTS admitted from 2000 to 2010 was retrospectively analyzed. Results Among 92 cases of GCTTS, the prevalent age was between 30 and 50 years. Most tumors were located on hands, and presented as early localized tumor. The average diameter of the tumor was 1.36 cm. The tissues were consisting of mononuclear cells, and multinucleate giant cells. The tumor cells grew actively in 29 cases, among whom, the nuclear mitosis was easily found in 6 cases; All the patients underwent local excision, and extensive local excision was performed on tbose with active growth; 15 cases lost follow-up and 9 cases recurred during 1 to 118 months of follow up. Conclusion The GCTTS is a kind of common be- nign soft tissue tumor, and can be diagnosed by pathomorphology. Local excision should be performed when diagnosis of the disease is confirmed.