进展性脑梗死患者血清D-二聚体、超敏C反应蛋白的变化及意义

Changes and significance of serum D-Dimer and high-sensitivity C reactive protein in patients with progressive ischemic stroke

目的观察进展性脑梗死(PIS)患者血清D-二聚体、超敏C反应蛋白(hs-CRP)的变化并探讨其临床意义。方法根据临床特征,将182例急性脑梗死患者分为进展组和非进展组,分别检测其血清D-二聚体、hs-CRP水平,并与30例非脑血管病患者(对照组)比较。结果脑梗死组血清D-二聚体、hs-CRP水平显著高于对照组(P均<0.01);进展组患者血清D-二聚体、hs-CRP水平显著高于非进展组(P均<0.01)。结论检测血清D-二聚体、hs-CRP水平有助于PIS的早期诊断。

Objective It is to observe the changes of serum D-Dimer and high-sensitivity Creactive protein（hs-CRP） levels in patients with progressive ischemic stroke,as well as to explore its clinical significance.Methods 182 cases of patients with acute cerebral infarction were divided into progressive ischemic stroke group and non-progressive ischemic stroke group according to the clinical characteristics.The level of serum D-Dimer and hs-CRP in both groups were measured,and compared with that of 30 cases with noncerebral disease which were as control group.Results Compared with control group,the level of serum D-Dimer and hs-CRP were significantly higher in cerebral infarction group（P0.01）.Compared with progressive ischemic stroke group,the level of serum D-Dimer and hs-CRP was significantly increased in patients with non-progressive ischemic stroke（P0.01）.Conclusion Determining the level of serum D-Dimer,hs-CRP may contribute to the early diagnosis of progressive ischemic stroke.