射频消融在扩张型心肌病合并预激综合征中的初步应用

Application of Radiofrequency Ablation in Wolff-Parkinson-White Syndrome Concomitant with Dilated Cardiomyopathy

目的探讨射频消融在扩张型心肌病合并预激综合征中的疗效。方法对6例有显性房室旁道的扩张型心肌病患者在药物治疗的基础上进行射频消融治疗,单纯药物治疗的12例扩张型心肌病作为对照组。术后对患者临床症状的改善进行随访,术前及术后6个月使用二维多普勒彩超测量患者左室舒张末期内径(LVDd)、左室射血分数(LVEF)及测定血浆中B型脑钠肽(BNP)水平。结果全部治疗组病例临床症状均有明显改善,术后LVDd、LVEF、BNP较术前明显改善(P<0.05),与对照组比较差异有统计学意义(P<0.05),无明显并发症。结论射频消融对扩张型心肌病合并预激综合征有较好的疗效,其机制可能与心脏再同步化有关。

Objective To study the curative effect of radiofrequency ablation on pre-excitation syndrome concomitant with dilated cardiomyopathy. Methods Radiofrequency ablation to accessory atrioventricular pathway was successfully performed in 6 cases with dilated cardiomyopathy.Twelve cases with dilated cardiomyopathy were received the common medical therapy and served as the control group.After the therapy,all the cases were followed up.The LVDd and LVEF were measured by the duplex Doppler Sonography.The plasma level of BNP was measured before and after the therapy. Results Cardiac performance of all the cases in radiofrequency ablation group was significantly improved after the therapy.The LVDd,LVEF and the plasma level of BNP were significantly improved as compared to before the treatment（P0.05）.There were statistically significant differences between radiofrequency ablation group and the control group（P0.05）.No complications occurred. Conclusions Radiofrequency ablation provides satisfactory therapeutic effect on pre-excitation syndrome concomitant with dilated cardiomyopathy,and the mechanism may be correlated with cardiac resynchronization.