Raman光谱法与经典方法验证阿司匹林固体分散体

To Verify Aspirin Solid Dispersion by Vibration Spectrometry and X-ray Diffraction Method

为了验证Raman光谱法验证固体分散体的可行性,采用熔融法制备阿司匹林固体分散体,并用Raman光谱法和经典方法(红外光谱法和X-射线衍射法)研究其分散性。三种鉴别方法得到一致的结果———阿司匹林以微晶状态分散在固体分散体中,且拉曼光谱法简单易行、快速直接、对样品无损伤,是一种新的理想的检查固体分散体分散性的方法。

Aspirin solid dispersion was prepared by melt method and was verified by Raman spectrometry and the classical methods （infrared spectrometry and X-ray powder diffrac- tometry） in order to test the feasibility of Raman spectrometry in identifying solid dispersion. The three methods obtained the same results-Aspirin was dispersed in the carrier in the state of microcrystalline. Raman spectrometry, simple, fast, direct and non-destructive, is an ideal method in examining the dispersivity of solid dispersion.