N-(4-羟基苯基)马来酰亚胺的溶解度测定及关联

Determination and Correlation of Solubilities of N-(4-hydroxyphenyl) Maleimide

引入激光监视技术和高效液相色谱分析,采用平衡法进行常压固液平衡的研究,对固体N-(4-羟基苯基)马来酰亚胺在无水乙醇、异丙醇、无水乙醇+水(水体积分数50%)和异丙醇+水(水体积分数50%)溶剂中的溶解度进行了研究。采用两参数方程和三参数方程分别对实验数据进行回归。结果表明,对于以上体系,三参数方程的拟合效果为佳。此外,所得到的N-(4-羟基苯基)马来酰亚胺在异丙醇溶剂中的溶解度实验数据,为合成N-(4-羟基苯基)马来酰亚胺的粗品进行分离纯化提供了相关数据。

The laser monitoring obseveration technique and high performance liquid chromatographic analysis technique are introduced in the reasearch of solid-liquid equilibrium at atmospheric pressure by belance method,the solubility of N-（4-hydroxyphenyl）maleimide in ethanol,isopropanol,ethanol＋50% water and ispropanol ＋50% water are measured.Then two parameter and three parameter equation are used to correlated the experimental data,the result shows three parameter equation is the best.In addition,the solubilities dato of N-（4-hydroxyphenyl） maleimide in isopropanol has been abtained is quite mecessary in the purification of crude N-（4-hydroxyphenyl） maleimide.