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DNA甲基化异常与恶性血液病关系的研究现状 被引量：2

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摘要 DNA甲基化是表观遗传调控的分子基础之一,DNA甲基化异常与恶性血液病的发生、发展有关。本文综述了多种功能基因甲基化异常和恶性血液病的关系及去甲基化药物治疗恶性血液病的现状和前景,旨为恶性血液病的治疗提供新的思路。
作者 蔡静怡 杨志刚
机构地区 广东医学院附属医院血液内科
出处 《广东医学院学报》 2011年第2期200-203,共4页 Journal of Guangdong Medical College
关键词 DNA甲基化 基因 恶性血液病 去甲基化治疗
分类号 R733 [医药卫生—肿瘤]
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参考文献22

  • 1Martinez-Delgado B,Melendez B,Cuadros M,et al.Frequent inactivation of the p73 gene by abnormal methylation or LOH in non-Hodgkin's lymphomas[J].Int J Cancer,2002,102(1):15-19.
  • 2Kawano S,Miller C W,Gombart A F,et al.Loss of p73 gene expression in leukemias/ lymphomas due to hypermethylation[J].Blood,1999,94(3):1113-1120.
  • 3Katzenellenbogen R A,Baylin S B,Herman J G.Hypermethylation of the DAP-Kinase CpG island is a commol alteration in B-cell malignancies[J].Blood,1 999,93(12):4347-4353.
  • 4Roman-Gomez J,Castillejo J A,Jimenez A,et al.5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1)gene and confers poor prognosis in acute lymphoblastic leukemia[J].Blood,2002,99(7):2291-2296.
  • 5Solomon P R,Munirajan A K,Tsuchida N,et al.Promoter hypermethylation analysis in myelodysplastic syndromes.Diagnostic & prognostic implication[J].Indian J Med Res,2008,127(1):52-57.
  • 6Herman J G,Jen J,Merlo A,et al.Hypermethylation-associated inactivation indicates a tumor suppressor role for p15 INK4B[J].Cancer Res,1996,56(4):722-727.
  • 7Christiansen D H,Andersen M K,Pedersen-Bjergaard J.Methylation of pl5INK4B is common is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia[J].Leukemia,2003,17(9):1813-1819.
  • 8Mateos M V,Garcia-Sanz R,López-Pérez R,et al.p16/INK 4a gene inactivation by hypermethylation is associated with aggressive variants of monoclonal gammopathies[J].Hematology Journal,2001,2(3):146-149.
  • 9Garcia M J,Martinez Delgado-B,Cebrian A,et al.Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-Positive non-Hodgkin's lymphomas[J].Am J PathoL 2002,161(3):1007-1013.
  • 10Mollemann M,Wolter M,Felsberg J,et al.Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors[J].Int J Cancer,2005,113 (3):379-385.

二级参考文献5

  • 1吕联煌 梁玉英 等.雷公藤内酯醇治疗急性白血病的研究[J].血液病实验与临床,1991,3:1-3.
  • 2Kiviharju TM,Lecane PS,Sellers RG,et al. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res,2002, 8:2666-2674.
  • 3Zhao G, Vaszar LT, Qiu D, et al. Anti-inflammatory effects of triptolide in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol, 2000, 279: L958-L966.
  • 4Shamon LA, Pezzuto JM, Graves J M, et al. Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii. Cancer Lett, 1997,112: 113-117.
  • 5金洁,MHauberg,林雄斌,RParwaresch.高三尖杉酯碱对人淋巴瘤细胞系Raji细胞作用的实验研究[J].中华血液学杂志,2000,21(10):546-547. 被引量：5

共引文献17

同被引文献51

  • 1Lyko F, Brown R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies[J]. J Natl Cancerlnst, 2005, 97(20) : 1 498.
  • 2Nan X, Ng HH, Johnson CA, et al. Transcriptional repr- ession by the methyl CpG binding protein MeCP2 in- volves a hist one deacetylase complex[J]. Nature, 1998, 393(6 683) :386.
  • 3Pakneshan P, Szyf M, Farias-Eisner R, et al. Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis[J]. J Biol Chem, 2004,279(30) :31 735.
  • 4Edlin R, Connock M, Tubeuf S, et al. Azacitidine for the treatment of myelodysplastic syndrome, chronic myelo- monocytic leukaemia and acute myeloid leukaemia[J]. Health TechnolAssess, 2010,14(Suppl 1) :69.
  • 5Issa JP. Decitabine[J]. Current Opinion in Oncology , 2003, 15(6) :446.
  • 6Scott SA, Lakshimikuttysamma A, Sheridan DP, et al. Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p154B demethylation and reexpression[J]. Exp Hematol, 2007,35(2) : 263.
  • 7Gao Z, Xu Z, Hung MS, et al. Procaine and procainami- de inhibit the Wnt canonical pathway by promoter demeth- ylation of WIF-I in lung cancer cells[J]. Oncol Rep, 2009, 22(6) : 1479.
  • 8Tada M, Imazeki F, Fukai K, et al. Procaine inhibits the proliferation and DNA methylation in human hepatoma cells[J]. Hepatol lnt, 2007, 1 (3) : 355.
  • 9Arce C, Segura-Pacheco B, Perez-Cardenas E, et al. Hy- dralazine target: from blood vessels to the epigenome[J].J Transl Med, 2006, 4:10.
  • 10Candelaria M, Gallardo-Rincon D, Arce C, et al. A ph- ase 1I study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resis- tance in refractory solid tumors[J]. Ann Oncol, 2007, 18 (9):1 529.

引证文献2

二级引证文献5

广东医学院学报
2011年 第2期

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