PX营养合剂对豚鼠急、慢性吸烟致气道高反应的影响

Effects of a mixture of nutrients on airway hyperresponsiveness induced by acute and chronic smoking in guinea pigs

目的：研究一种由本室研制的营养合剂（简称PX）对豚鼠急、慢性吸烟所致气道商反应的影响。方法：采用体积站记群方法测定气过反应性。结果：发现豚鼠进食5周PX能显著降低由急、慢性吸烟所致的气道高反应：①慢性吸烟对照组（SC组）使FEV0.1下降20％所需组胺阈浓度（PC20FEV0.1）为（0．113±0．022）mg/mL；而慢性吸烟加PX组（SP组）为（0．302±0.020）mg/mL（P＜0．01）②急性吸烟后SC组各项肺功能指标如用力肺活量（FVC）、0．1s用力呼气量（FEV0.1）、最大中期呼气流速（MMEF）、最大呼气流速（PEF）等均显著下降（P＜0．05），而SP组上述各项指标均无显著变化（P＞0．05）。肺形态学检查显示SC组气道出现上皮损伤及炎症病变，而联组病变明显技光组轻。结论：职能降低由急、慢性吸烟所引起的气道高反应。

The effects of a mixture of nutrients (simply named Px) on airway hyperresponsiveness(AHR) in-duced by acute and chronic smoking were studied in guinea pig METHODS: Airway responsiveness was measured by usingbody pneumotachograph,RESULTS: AHR induced by acute or chronic smoking be reduced significantly by feedingwith PX diet for 35 days. The provocative concentration of histamine causing a 20% decrease in FEV.0.1)in SPgroup (smoking and PX diet group ) was (0.302±0.020e) mg/mL,significantly highe than that of SC group(smoking con-trol group) (0. 113 ± 0.022) mg/mL (P < 0.0l); Acute smoking caused a significant decrease invarious pulmonary functtional parameters.such as forced expiratory volume (0. 1s), maximum midexpiratory flow, peak expiratory flow,forced vitalcapacity in SC group (P <0.05), but there was no significant influence could be observed in SP group (P >0.05). Pul-monary morphogical studies showed that the pathologic changes of SC group were much more serious than those of SP group:very obvious epithelial damage and inflammation like changes be seen for the SC grop. CONCLUSION: PX couldreduce AHR indutal by acute or chronic smoking.