糖尿病患者罹患结直肠癌危险性的Meta分析

Relationship between Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-analysis

目的系统评价糖尿病与结直肠癌发生率的相关性,以期为糖尿病患者结直肠癌的早期筛查提供较为客观的依据。方法计算机检索MEDLINE和EMbase,检索时限为1990年1月至2010年7月,查找糖尿病患者发生结直肠癌风险性的相关队列研究,按照纳入排除标准进行文献筛选、资料提取和质量评价后,采用RevMan 4.3软件进行Meta分析。结果共纳入17项研究,包括1 690 869例研究对象。Meta分析结果显示:糖尿病患者结直肠癌发生率较对照组高,差异有统计学意义[16.50‰vs.10.13‰;OR=1.43,95%CI(1.29,1.60)]。亚组分析显示,无论男性和女性糖尿病患者,其患结直肠癌危险性均较对照组高;男性糖尿病患者风险稍高于女性(OR:1.47 vs.1.41)。结论糖尿病是结直肠癌发生的危险因素之一。

Objective To systematically review the correlation between diabetes and the incidence rate of colorectal cancer,so as to provide objective proof for early screening diabetic patients with colorectal cancer.Methods The databases such as MEDLINE and EMbase published from January 1990 to July 2010 were searched to include cohort studies.The meta-analysis including seventeen qualified studies was performed by using the Cochrane Collaboration＇s RevMan 4.3 software.Results The results of meta-analyses of 17 cohort studies involving 1 690 869 participants indicated that the diabetes patients had a higher incidence rate of colorectal cancer compared with the control group（16.50‰ vs.10.13‰）.The odds ratio（OR） was 1.43,and the 95% confidence interval（CI） was from 1.29 to 1.60.The results were consistent by sex compared with the control group,although the OR for colorectal cancer in diabetes was little higher in males than females（1.47 vs.1.41）.Conclusion Diabetes mellitus is a risk factor of inducing colorectal cancer.