精氨酸脱敏牙膏治疗牙本质敏感的Meta分析

Arginine-Containing Desensitizing Toothpaste for Dentine Hypersensitivity: A Meta-analysis

目的评价精氨酸脱敏牙膏治疗牙本质敏感的疗效。方法计算机检索CNKI、PubMed、Web of Science和Cochrane图书馆临床对照试验资料库(2008年第4期),并辅以Google搜索引擎进行检索(检索时间截至2010年3月),搜集精氨酸脱敏牙膏治疗牙本质敏感的随机对照试验(RCT)。对纳入文献进行资料提取和质量评价后,采用RevMan 5.0软件进行Meta分析。结果共纳入5个RCT,包括397例患者。Meta分析结果显示,精氨酸牙膏与含钾牙膏比较,在第8周触压敏感测试[SMD=1.32,95%CI(0.68,1.96)]及冷空气喷吹检测[SMD=–0.77,95%CI(–1.22,–0.32)]上,其差异均有统计学意义,精氨酸牙膏治疗牙本质敏感效果更佳。结论现有文献表明,精氨酸牙膏治疗牙本质敏感效果优于含钾牙膏。但因纳入RCT数较少,样本量较小,上述结论尚待更多高质量、大样本的RCT予以进一步证实。

Objective To estimate the effect of desensitizing toothpaste containing arginine on dentine hypersensitivity. Methods Such databases as CNKI,PubMed,Web of Science and Cochrane Trials Register（Issue 4,2008） were retrieved,and Google was used as a supplementary tool to search the information up to March 2010.Randomized controlled trials（RCTs） of treating dentine hypersensitivity with arginine-containing toothpaste were included,and the relevant information was extracted and the quality evaluation was undertaken.Meta-analyses were performed with RevMan 5.0 soft ware.Results Five RCTs with 397 patients were included.Th e results of meta-analyses showed that at 8 weeks, arginine-containing toothpaste was signifi cantly different from potassium-containing toothpaste in terms of tactile sensitivity test（SMD=1.32,95%CI 0.68 to 1.96） and air blast test（SMD= –0.77,95%CI –1.22 to 0.32） with a better therapeutic effect.Conclusion Current literature evidence shows that the arginine-containing toothpaste is effective for the dentine hypersensitivity.However,this study is based on a small number of RCTs and samples,so further studies with high-quality and large-sample RCTs are needed.