摘要
目的探讨TGF-β1及ERK2在宫颈癌组织中的表达及其临床意义。方法采用免疫组化(S-P法)检测80例宫颈癌组织、30例正常宫颈组织中TGF-β1和ERK2的表达情况,分析其与宫颈癌各临床病理因素的关系。结果 TGF-β1和ERK2在宫颈癌中阳性表达率分别为65%和75%,明显高于对照组(16.67%和13.33%,P<0.01);TGF-β1和ERK2阳性表达率随临床分期(≤Ⅱa期和≥Ⅱb期)的增高而增加(P<0.05),病理分级的降低而增加(P<0.01),有淋巴结转移者高于无转移者(P<0.01);TGF-β1与ERK2在宫颈癌组织中的表达呈正相关(r=0.605,P<0.01)。结论 TGF-β1及ERK2的表达与宫颈癌的生长、浸润、转移等生物学行为关系密切。在宫颈癌的发生发展过程中发挥重要的作用。
Objective To investigate the expressions and clinical significance of TGF-β1 and ERK2 in the progression of cervical carcinoma.Methods The expression of TGF-β1 and ERK2 were determined in 80 cases of cervical carcinoma and 30 normal cervical epithelium by immunohistochemical SP method.The expression of TGF-B1 and Smad4 was then correlated with clinicopathological characteristics.Results The positive expression of TGF-β1 and ERK2 were 65%and 75%,respectively.There are significantly higher positive expression rates of TGF-β1 and ERK2 than those in the control（P0.01,respectively）,with the clinical stage（≤Ⅱa,≥Ⅱb）and pathological grade increasing.The positive expression rates of TGF-β1 and ERK2 were significantly high in cervical carcinomas.The positive expression rates of TGF-β1 and ERK2 in human cervical carcinomas without lymph node metastasis were lower than those with lymph node metastasis（P0.01,respectively）.The expression of ERK2 positive related to TGF-β1 in cervical carcinomas.Conclusion The expression levels of TGF-β1 and ERK2 were related significantly to the invasive growth and metastasis of human cervical carcinomas.They play an important role during the occurrence and development of human cervical carcinomas.
出处
《西部医学》
2011年第5期828-831,共4页
Medical Journal of West China
基金
四川省科技厅资助课题(NO:07SG004-002)
