常州市两次麻疹强化免疫效果比较

Comparison of Two Measles Vaccine Supplement Immunity Activity in Changzhou City

目的对比常州市两次麻疹减毒活疫苗(MV)强化免疫(SIA)的效果,探讨麻疹控制措施。方法用描述流行病学分析方法,对比常州市两次麻疹SIA效果。结果 2007年11月MV SIA后,2008年麻疹报告发病率为24.13/10万,较2007年上升91.66%;SIA后8个月麻疹发病同比平均上升118.57%;<15岁年龄组发病构成比同比上升11.17%;SIA前后常住、流动儿童麻疹疫苗接种率差异无统计学意义(P>0.05)。2009年4月开展MVSIA,SIA前麻疹发病同比平均上升221.30%;SIA后8个月麻疹发病同比平均下降88.69%,<15岁年龄组发病构成比同比下降50.03%;SIA后流动儿童麻疹疫苗接种率明显提高(P<0.05)。结论 2007年MV SIA低覆盖是SIA后麻疹高发的主要原因,2009年开展的高质量MV SIA成功削平了麻疹发病高峰。政府参与、多部门配合是开展高质量MV SIA的基础。

Objective To Contrast two measles attenuated live vaccine（MV ） supplementary immunization activity（SIA） in Changzhou city and approach measures of measles elimination.Methods Comparison of the different characteristics between two MV SIA was conducted with descriptive epidemiology. Results After SIA in Nov.2007,the reported measles incidence was 24.13/100 000,and increased by 91.60%in 2008 than that in 2007;During the following 8 months after MV SIA,the reported measles incidence increased by 118.57%averagely;The constituent ratio of the group in which the age was less than 15 increased by 11.17%to the corresponding period of last year.There was no obvions change for the inoculation rate of measles from settled and floating population.Before SIA in Apr.2009,the reported measles incidence increased by 221.30%averagely and after SIA in 2009,the reported measles incidence decreased by 88.69%averagely;The constituent ratio the measles incidence in the group in which the age was less than 15 decreased 50.03%to the corresponding period of last year;The inoculation rate of measles in floating population increased obviously.Conclusion Low coverage of MV is the main cause of high measles incidence after SIA in 2007.The peak of measles incidence is smoothed through using high quality SIA in 2009.The Government participation and departments coordination are very important,when a good MV SIA is carried out.