大鼠移植性肝癌栓塞化疗及栓塞内放疗的实验研究

EXPERIMENTAL STUDY ON THE EFFECTS OF CHEMOEMBOLIZATION AND INTRA RADIOTHERAPEUTIC EMBOLIZATION IN RATS WITH IMPLANTED HEPATIC TUMOR

为了探讨栓塞化疗及栓塞内放疗对大鼠移植性肝癌的治疗效果及机理，本文采用Ｗａｌｋｅｒ２５６ 肝癌瘤株接种于６０ 只ＳＤ大鼠肝脏上，１ 周后分３ 组进行不同治疗，观察治疗效果并进行比较。结果发现，两种治疗方法的肿瘤体积比、肿瘤坏死率及肿瘤生长率无明显差别（ Ｐ＞ ０．０５），对肝功酶类的影响有显著差别（ Ｐ＜ ００５）；经不同方法治疗后，癌灶中均残留存活的癌细胞。表明两种治疗方法均对移植性肝癌有明显治疗效果。

In order to study the effects and mechanism of chemoembolization and intra radiotherapeutic embolization after hepatic tumor implentation in rats,walker 256 hepatic tumor cells were implanted into the liver of 60 SD rats which were divided into 3 groups and different therapy were performed, the effects of two kinds of therapy were observed and compared.We found that the rate of tumor size, tumor necortic rate and tumor growth rate had significant differences between the two kinds of therapy (P>0.05) and there was significant difference in effects on hepatic function (P<0.05).After different treatments, survival cancer cells were found in the tumor foci.It is suggested that both of the methods can exert obvious effects on implanted hepatic tumor, but there are survival cancer cells after single treatment.